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EC number: 947-572-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a guinea pig study already performed in the 1960s the test substance (formulated in ether) revealed a skin sensitizing potential at a challenge concentration of 1 %.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin sensitisation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 406), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods. - GLP compliance:
- no
- Type of study:
- other: a kind of Buehler test: induction and challenge with topical application
- Justification for non-LLNA method:
- The LLNA has not yet been invented.
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No information available
- Route:
- epicutaneous, open
- Vehicle:
- other: ether
- Concentration / amount:
- 10 %
- Day(s)/duration:
- The same application as on day 0 is carried out on the same test area daily over 8 days (= 9 treatments)
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- epicutaneous, open
- Vehicle:
- other: ether
- Concentration / amount:
- 1 %
- Day(s)/duration:
- once/8, 12 and 24 h after application skin reactions were observed
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- 5 (test group); 5 (control group)
- Details on study design:
- INDUCTION (topical with regard to test substance treated and control group):
The left and right flanks of the guinea pigs were shorn (ca. 25 cm²) one day prior to the application.
The test substance in a suitable vehicle was applied by wiping the shaved skin of the left flank with a soaked cotton pad three times one after another. The same application as on day 0 was carried out on the same test area of the same flank on the following days until a significant skin irritation is observed.
The vehicle only is applied once in a similar manner to that used for the treated group in the control group.
CHALLENGE (topical with regard to test substance treated and control group):
Ca. one week (8-10 days) after the last application of the induction phase the left and right flanks of the guinea pigs were shorn again. Approximately 24 hours later the test substance, at a non-irritant concentration (a tenth of the concentration used for induction) was once applied to untreated right flank of treated animals. 8, 12 and 24 hours later the skin reactions are observed and recorded - Challenge controls:
- see "Details on study design"
- Positive control substance(s):
- not specified
- Positive control results:
- not applicable
- Reading:
- other: single result is recorded across the three reading times (8, 12, 24 hours)
- Hours after challenge:
- 8
- Group:
- test chemical
- Dose level:
- 1 % test substance formulation
- No. with + reactions:
- 5
- Total no. in group:
- 5
- Clinical observations:
- none
- Remarks on result:
- positive indication of skin sensitisation
- Interpretation of results:
- other: sensitising
- Executive summary:
In a guinea pig study already performed in the 1960s the test substance (formulated in ether) revealed a skin sensitizing potential at a challenge concentration of 1 %.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
On the basis of the available information a classification according to Regulation (EC) No 1272/2008, Annex I, is warranted:
Skin Sens. Cat.1 H317
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