Registration Dossier
Registration Dossier
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EC number: 204-029-1 | CAS number: 113-48-4
Endpoint summary
Administrative data
Description of key information
A hydrolysis study was conducted with MGK 264 at a nominal test concentration of 1.0 μg/mL in four aqueous buffer solutions: pH5,10.0 mM acetate buffer; pH 7, 10.0 mM Tris (hydroxymethyl) aminomethane (TRIS); pH 7, 10.0 mM N-2 -hydroxyethyl-piperazine-N'-2 -ethanesulfonic acid (HEPES); and pH 9, 10.0 mM borate buffer. The data generated during this study show that [14C]-MGK 264 in aqueous solution over the pH range of 5 -9 at 25°C for 30 days does not hydrolyze. Also, [14C]-MGK 264 is not affected by buffer type at pH 7. Due to the lack of degradation, the rate constants were determined to be statistically not significantly different from 0, yielding infinite half-lives.
An aqueous photolysis study was conducted with MGK 264 at a nominal test concentration of 1.0 µg/mL in aqueous solution buffered at pH 7 in 10.0 mM Tris (hydroxymethyl) aminomethane. The samples were photolyzed using a xenon arc lamp in a temperature-controlled photolysis chamber. The data generated during this study show that [14C]-MGK 264 in aqueous solution at pH 7, 25°C, and exposed to light for 30 days does not photolyze. Due to the lack of degradation, the rate constant was determined to be statistically not significantly different from 0, yielding an infinite half-life.
These studies indicate that abiotic degradation is not a major route of degradation for MGK 264 in the environment.
Additional information
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