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Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method

Test material

Constituent 1
Test material form:
solid

Results and discussion

Water solubility
Key result
Water solubility:
3.5 mg/L
Temp.:
20 °C
pH:
>= 6 - <= 6.3

Any other information on results incl. tables

Individual results

 

1st column

2ndcolumn

3rdcolumn

2ndcolumn

(extended)

 

Gradient A

Gradient B

Gradient B

Gradient B

Fraction

concentration of test item

[mg/l]

pH

concentration of test item

[mg/l]

pH

concentration of test item

[mg/l]

pH

concentration of test item

[mg/l]

pH

11

3.5277**

6.1

3.4014*

6.2

3.5607

6.3

-

-

12

3.6077**

6.1

3.0237*

6.2

3.5805

6.3

-

-

13

3.5137**

6.1

3.1692*

6.2

3.5527

6.3

3.2267*

6.0

14

3.4776**

6.1

3.1815*

6.2

3.5770

6.3

3.3615

6.1

15

3.4483**

6.1

3.1208*

6.2

3.6163

6.3

3.3681

6.1

16

 

 

 

 

 

 

3.3894

6.0

17

 

 

 

 

 

 

3.3459

6.1

18

 

 

 

 

 

 

3.3698

6.0

19

 

 

 

 

 

 

3.3899

6.0

20

 

 

 

 

 

 

3.3762

6.1

Water used

 

6.2

 

6.1

 

6.2

 

6.2

Mean

3.5±0.1

 

-

 

3.6 ± 0.1

 

3.4±0.1

 

 

Total mean (3rdcolumn and 2ndcolumn extended) 3.5 ± 0.1mg/L

Remark: All results are calculated with not rounded values.

* not used for calculation because of increasing values (equilibration time not sufficient).

** not used for calculation of total mean because of slightly decreasing values; stability of test item confirmed by double

injection of each fraction/ injection after storage in the dark (3.1776 mg/L) and at light (3.2844 mg/L) for one day (3.2805

mg/L without storage). Column elution was repeated and the sampling of the fractions were extended (see "2nd column

extended")

Applicant's summary and conclusion