Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation tests
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guidline GLP study available. The evaluation was published by an official EU Committee, which is considered as scientifically sound source of information and tehrefore considered to be relevant and valid for the substance evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Principles of method if other than guideline:
- The SCCNFP evaluated the use of different stabilisers in CIT/MIT technical-grade active ingredient (TGAI) and its diluted aqueous solutions, for use in cosmetics. To this end, the stability of CIT/MIT in TGAI and its aqueous dilutions for use in the cosmetics industry were discussed. Degradation pathways and mechanisms were elucidated.
- GLP compliance:
- no
Test material
Constituent 1
Study design
- Inoculum or test system:
- not specified
- Remarks:
- No information is given on materials and methods, because the document represents an evaluation of a dossier, and the dossier itself is not available.
Results and discussion
- Test performance:
- No detailed information are available
% Degradation
- Remarks on result:
- other: Dossier evaluation
- Remarks:
- No information is given on materials and methods, because the document represents an evaluation of a dossier, and the dossier itself is not available.
- Transformation products:
- no
- Details on results:
- The following text is a citation from the document, page 4 (Notes: the acronym MCI/MI is used for CIT/MIT in the document; references given as numbers in the original text were omitted here since they are anyway not available):
“According to the information provided in the dossier, the instability of commercial MCI/MI mixtures is due to two factors, i.e. the inherent instability of the isothiazolinone molecules, and residual impurities of the manufacturing processes.The sulphur-nitrogen bond of the isothiazolinone ring represents an electrophilic centre that may react easily with nucleophilic substances. In the MCI molecule, a further electrophilic centre, the vinyl-activated chlorine atom in the neighbourhood of the sulphur-nitrogen bond is responsible for increasing the instability of MCI in comparison to MI molecule.Deactivation is thought to proceed by means of a cascade of reactions, initiated by ring opening, loss of chlorine and sulphur, and subsequent formation of N-methylmalonamic acid. The degradation then proceeds through malonamic, malonic, acetic, and formic acids to carbon dioxide and methylamine, accompanied by several side products (N methylglyoxylamide, ethylene glycol, urea). Isothiazolinone-1-oxides are also derived by enzymic oxidation of disulphanes, elemental sulphur (as a result of breakdown of sulphurous acids) and hydrogen sulphide. This is a strong nucleophile attacking the ring and accelerating the decomposition in a self-perpetuating autocatalytic sequence of reactions, which is more rapid at higher concentrations of the MCI/MI solutions.In pure aqueous solutions the ring opening is initiated by simple hydrolytic cleavage of the S-N bond, which is the reaction occurring in the presence of strong nucleophiles such as primary and secondary amines and particularly thiol derivatives.”
Any other information on results incl. tables
Several mechanisms for degradation are possible, all starting with nucleophilic attack leading to cleavage of the N-S bond and thus ring opening. This leads to deactivation due to the loss of the active moiety.
The central intermediate metabolite is N-methylmalonamic acid. Terminal metabolites are generally small, polar and mostly naturally occurring molecules such as urea, formic acid, acetic acid; and methylamine and ethylene glycol. Mineralisation to carbon dioxide also occurs.
Ring opening in environmental media was considered to proceed mainly by attack of amines or thiols. Such groups are abundant in microbially viable media and occur at especially highly concentrations in activated sewage sludge.
An autocatalytic degradation mechanism was also proposed in the evaluation. This should be relevant only for concentrated solutions of CIT/MIT in technical applications. In environmental media, CIT/MIT is highly diluted and autocatalysis is likely to remain negligible.
CIT was expected to be degraded more rapidly than MIT, because the electrophilic chlorine activates the N-S bond for nucleophilic attack.
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The metabolic pathways of CIT/MIT were evaluated in technical-grade active ingredient and its diluted aqueous solutions. Degradation mechanisms and pathways were proposed (see attached document).
- Executive summary:
The statement is giving the following information: "In pure aqueous solutions the ring openeing [of CIT and MIT] is initiated by simple hydrolytic cleavage of the S-N-bond, which is the reaction occuring in the presence of strong nucleophiles such as primary and secondary amines and particularly thiol derivatives". A scheme for autocatalytic degradation is given.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Iako ECHA većinu materijala na ovim stranicama osigurava na vašem jeziku, dio ove stranice samo je na engleskom. Dodatne informacije o politici višejezičnosti ECHA-e.
Dobro došli na stranice ECHA-e Ove stranice ne podržavaju potpuno Internet Explorer 7 (i njegove ranije inačice). Preuzmite noviju inačicu Internet Explorera.
Na ovom portalu koristimo kolačiće kako bismo vam osigurali najbolje iskustvo njegova pregledavanja.
Saznajte više o tome kako upotrebljavamo kolačiće.