Registration Dossier
Registration Dossier
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EC number: 200-782-5 | CAS number: 72-48-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Presence and estrogenicity of anthracene derivates in coastal Japanese waters
- Author:
- Ryo Kurihara et al.
- Year:
- 2 005
- Bibliographic source:
- Environmental Toxicology and Chemistry, Vol. 24, No. 8, pp. 1984–1993, 2005
Materials and methods
- Type of study / information:
- anthracene and hydroxy-anthraquinones (hATQs) for estrogenic activity (Endocrine disruptor)
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dihydroxyanthraquinone
- EC Number:
- 200-782-5
- EC Name:
- 1,2-dihydroxyanthraquinone
- Cas Number:
- 72-48-0
- Molecular formula:
- C14H8O4
- IUPAC Name:
- 1,2-dihydroxy-9,10-dihydroanthracene-9,10-dione
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- 97% pure
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- In an estrogenicity assay system with the yeast two-hybrid system 1,2-dihydroxyaanthraquinone showed estrogen agonist activity,
- Executive summary:
In this study the yeast two-hybrid system was used to evaluate the estrogenic activity of hydroxy-anthraquinones. Estrogen agonist and antagonist tests were carried out with or without rat liver S9.
A receptor-binding assay, a Michigan Cancer Foundation-7 (MCF-7) cell proliferation assay (estrogen screen, E-screen), and reporter gene assays in animal cell lines was used to evaluate estrogenic activity.
1,2-dihydroxyaanthraquinone showed toxicity to yeast especially with rat liver S9 than with no S9. In this estrogenicity assay system with the yeast two-hybrid system 1,2-dihydroxyaanthraquinone showed estrogen agonist activity.
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