Registration Dossier
Registration Dossier
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EC number: 296-117-1 | CAS number: 92257-28-8
Endpoint summary
Administrative data
Description of key information
Adsorption:
Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical N-(2-ethylhexyl)-1- [4-(2-phenyldiazen-1-yl)phenyl] naphthalen-2-amine (CAS No. 92257 -28 -8). The soil adsorption coefficient i.e Koc value of N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl) phenyl]naphthalen-2-amine was estimated to be 6600000 L/kg (log Koc= 6.819) by means of MCI method (at 25 deg C). This Koc value indicates that the substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Additional information
Adsorption:
Various predicted and experimental data for the target compound N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the adsorption end point which are summarized as below:
In the first weight of evidence Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical N-(2-ethylhexyl)-1- [4-(2-phenyldiazen-1-yl)phenyl] naphthalen-2-amine (CAS No. 92257 -28 -8). The soil adsorption coefficient i.e Koc value of N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl) phenyl]naphthalen-2-amine was estimated to be 6600000 L/kg (log Koc= 6.819) by means of MCI method (at 25 deg C). This Koc value indicates that the substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
First predicted data was supported by the second supporting study for the structurally and functionally similar read across chemical from authoritative database. The Koc value for chemical was estimated by using a structure estimation method based on molecular connectivity indices. The estimated Koc value was 130000 dimensionless and log Koc is 5.11 this log Koc value suggests that test chemical has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Similarly another read across chemical from authoritative database 2017 was also used as it supports the behavior of chemical. Adsorption study was conducted for estimating the adsorption coefficient (Koc) value of test chemical. The adsorption coefficient (Koc) value was calculated using a structure estimation method based on molecular connectivity indices. The adsorption coefficient (Koc) value of test substance was estimated to be 4800000 (Log Koc = 6.681). This Koc value indicates that the substance has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Thus based on the overall adsorption result it is concluded that the test substance have very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
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