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EC number: 233-279-4 | CAS number: 10102-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 04 April 2013 - 13 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 436
- Deviations:
- not specified
- Principles of method if other than guideline:
- This study is submitted as supporting data as the data are taken from an acute inhalation study where the substance was ground prior to generation of an atmosphere. The study does not therefore necessarily reflect the particle size of the substance as it is placed on the market.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Inspection: 10 July 2012, Date of signature: 30 November 2012
- Type of distribution:
- other: Gravimetric
- Specific details on test material used for the study:
- Sponsor's identification: IP37: Copper (II)-pyrophosphate
Description: Pale green powder
CAS No. 10102-90-6
EC No. 233-279-4
Batch number: 9000022795
Purity: > 80 % (based on Cu content > 34 %)
Impurities: < 18 % water, < 2 % free othophosphate, pyrophosphate
Expiry Date: 29 September 2014
Storage conditions: Room temperature, in the dark - Mass median aerodynamic diameter:
- >= 1.99 - <= 3.06 µm
- Geometric standard deviation:
- >= 2.14 - <= 2.67
- Conclusions:
- The Mean Mass Median Aerodynamic Diameter was reported to be 3.06 μm for group 1 animals and 1.99 μm for group 2 animals. The inhalable fraction (rat) of the test material ( % <4 μm) was 60.9% for group 1 and 82.3% for group 2, which would allow the test material to reach upper and lower regions of the respiratory tract of the test animal.
- Executive summary:
The Mean Mass Median Aerodynamic Diameter was reported to be 3.06 μm for group 1 animals and 1.99 μm for group 2 animals. The inhalable fraction (rat) of the test material ( % <4 μm) was 60.9% for group 1 and 82.3% for group 2, which would allow the test material to reach upper and lower regions of the respiratory tract of the test animal.
This study is conducted according to an appropriate guideline and under the conditions of GLP, the study is therefore considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint.
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study was completed on 18th March
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268 ' Determination of Particle Size Distribution, Fibre Length and Diameter Distribution' of Chemical Substances (2002).
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 10 July 2012, Date of signature: 30 November 2012
- Type of method:
- sieving
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- -Identification: IP37: Copper (II)-pyrophosphate
- Description: Pale blue powder
- Batch number: 9000022795
- Composition: P2O5 (39.15 % w/w), CuO (43.52 % w/w)
- Expiry date: 29 September 2014
- Storage Conditions: Room temperature, in the dark - Key result
- Percentile:
- D90
- Mean:
- <= 100 µm
- Remarks on result:
- other: no standard deviation determined
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 94.6 %
- Conclusions:
- The proportion of the test material having an inhalable particle size of less than 100 µm was determined to be 94.6 %, therefore the test item has been considered to be essentially inhalable.
No further particle size fractions were assessed for the test item. - Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test material was sieved in an alpine air jet sieving machine.
- GLP compliance:
- no
- Type of method:
- sieving
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): copper (II) pyrophosphate (Kupferhydroxidphosphat)
- Key result
- Percentile:
- D99
- Mean:
- <= 100 µm
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 100 %
- Conclusions:
- 100% of particles were found to be < 100 µm in diameter and as such the particle size distribution indicates copper(II) pyrophosphate is an inhalation risk (a significant proportion of the particles are present at < 100 µm).
- Executive summary:
100 % of particles were found to be < 100 µm in diameter and as such the particle size distribution indicates copper(II) pyrophosphate is an inhalation risk (a significant proportion of the particles are present at < 100 µm).
This study is considered to be appropriate and reliable for use as a key study in accordance with Regulation (EC) No. 1907/2006 (REACH). No further testing is required.
Referenceopen allclose all
The particle size analysis of the atmosphere drawn from the animals’ breathing zone, was as follows:
Group Number |
Mean Achieved Atmosphere Concentration (mg/L) |
Mean Mass Median Aerodynamic Diameter (μm) |
Inhalable Fraction (% <4 μm) |
Geometric Standard Deviation |
1 |
5.16 |
3.06 |
60.9 |
2.67 |
2 |
1.08 |
1.99 |
82.3 |
2.14 |
The results of the sieving are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve |
12.52 g |
Mass of test item passed through sieve |
11.84 g |
Proportion of test item < 100µm |
94.6% |
Description of key information
The proportion of the test item having an inhalable size of less than 100 µm was determined to be 94.6 % using a sieve method.
Additional information
Three studies exist (company test data, MMAD as reported in an OECD 403 study and a particle size distribution study). The results from the particle size distribution study have been chosen as the key study.
The proportion of the test item having an inhalable size of less than 100 µm was determined to be 94.6 % using a sieve method, procedure designed to be compatible with European Commission Technical Guidance Document EUR 20268 ' Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002)'. No further particle size fractions were assessed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.