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EC number: 947-255-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 9 to 11 Octobre 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP compliance programme (inspected on 13-14 October 2014 / signed on 8 April 2015)
- Type of method:
- differential scanning calorimetry
- Key result
- Boiling pt.:
- >= 178.26 - <= 179.13 °C
- Atm. press.:
- ca. 1 013 hPa
- Remarks on result:
- other: atmospheric pressure not provided but assumed to be normal atmospheric pressure (1013 hPa)
- Conclusions:
- The boiling point of the substance was determined under experimental circumstances within the following range: (178.26 – 179.13 °C) (451.41 – 452.28 K) using DSC method.
- Executive summary:
The boiling point of the test item was measured under GLP according to OECD 103 / EU A2 guideline, by DSC.
3 runs were performed. One event could be detected in the second and the third run. The event was endothermand was considered to be a representative boiling point value for the test substance.
As the replicates were not within accuracy limits of the method, the result is stated as a range. Finally the boiling point of the substance was determined under these circunstances within the following range: (178.26 – 179.13 °C) (451.41 – 452.28 K).
These values are the results of two independent measurements using DSC method.
We noted a large difference with the result obtained during the preliminary test which may be due to the volatilisation of the most volatile constituents of the substance. Note also that these results may vary with the substance composition and should therefore be considered with caution.
No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Reference
Results
Pre-Test following Siwoloboff
A small amount of the test item was heated in a test tube with a Bunsen burner.
The following observations were noted:
Table 4.3/1.- Values Observations
Observation |
Temperatures |
Formation of single bubbles |
52 °C |
Bubbles came faster |
83°C |
Bubbles came fast and in series |
110°C |
Building of a chain of bubbles |
143°C |
Many chains of bubbles (heating stopped) |
150°C |
Broke of the chain of bubbles |
136°C |
After broke of the chain of bubbles, test item was heated again to 200 °C |
|
Many chains of bubbles, volume of liquid expanded |
200 °C |
After cooling down no visual changes and no signs for decomposition or polymerisation were visible. |
|
Security Pre-test for the DSC instrument
The crucible was found visual unchanged after reaching a temperature of 420°C. After cooling down the weight was recorded with 46.05 mg, leaving a residue of 0.14 mg.
Calibration
After calibration with indium and zinc the measurement of indium yielded the following values:
Table 4.3/2.-Values DSC Indium
Expected Melting point |
Measured Melting point (Onset) |
Expected Energy |
Measured Energy |
Assessment |
156.6 ± 1.0°C |
156.60 °C |
28.45 ± 1.0 J/g |
27.72 J/g |
OK |
The measurement of indium after calibration met the validity criteria.
DSC Measurement of the Test Item
Table 4.3/3.- Values results
Event |
in °C |
in K |
First Determination |
no event |
- |
Second Determination |
178.26 |
451.41 |
Third Determination |
179.13 |
452.28 |
Min |
178.26 |
451.41 |
Table 4.3/4.-Values Observations
Mass test item |
Mass crucible (before measurement): |
Mass crucible (after measurement): |
Observations |
|
First Measurement |
3.17 mg |
48.43 mg |
47.54 mg |
After the test the crucible was visually unchanged |
Second Measurement
|
4.66 mg |
50.44 mg |
45.91 mg |
After the test the crucible was visually unchanged |
Third Measurement
|
4.98 mg |
50.64 mg |
45.80 mg |
After the test the crucible was visually unchanged |
Validity
As the criterion of≤0.5 K was not fulfilled a boiling range was stated.
Discussion
The determination of the boiling point of the test item was performed via DSC (differential scanning calorimetry).
A preliminary test conducted according the Siwoloboff method, showed the formation of bubbles from about 52°C, building of bubbles’ chain at about 143°C, many chains of bubbles at about 150°C (stop of heating) and break of the bubbles’ chain at about 136°C.
Three determinations were performed using the DSC method. The first in the range from 15°C to 165°C, but no event could be detected. Therefore, the range of tested temperatures was adapted.
In the two other runs, conducted in the range from 15°C to 420°C,one small endothermic event was detected with a slightly shift of the baseline.This event was considered to be a representative boiling point value for the test substance.
As the replicates were not within accuracy limits of the method, the result is stated as a range.
Finally the boiling point of the substance was determined under these circumstances within the following range:
(178.26 – 179.13 °C) (451.41 – 452.28 K)
These values are the results of two independent measurements using DSC method.
We noted a large difference with the result obtained during the preliminary test, which may be due to the volatilisation of the most volatile constituents of the substance. Note also that these results may vary with the substance composition and should therefore be considered with caution.
No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.
Description of key information
The boiling range of the substance was determined under experimental circumstances within the following range: (178.26 – 179.13 °C) (451.41 – 452.28 K) using DSC method.
Key value for chemical safety assessment
Additional information
A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result being expressed as a range, it cannot be retained as (single) key data.
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