Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 417-440-8 | CAS number: 2516-92-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Version / remarks:
- November, 1984.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,10-bis(2,2,6,6-tetramethyl-1-piperidinyloxy)-1,10-dioxodecane
- EC Number:
- 417-440-8
- EC Name:
- 1,10-bis(2,2,6,6-tetramethyl-1-piperidinyloxy)-1,10-dioxodecane
- Cas Number:
- 2516-92-9
- Molecular formula:
- C28 H50 N2 O6
- IUPAC Name:
- bis(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) decanedioate
- Details on test material:
- Identification code (lab) = TKA 40075
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
Ray Nichols Rabbitry, Lumberton, Texas
- Age at study initiation:
Young adult (3 to 6 months)
- Weight at study initiation:
Not specified
- Acclimation period: At least five days
Cage Type: Suspended, wire bottom, stainless steel Housing: One per cage
Transfer to Clean Cages: Weekly
Litter Pan Linmg: Paper
Litter Pan Lining Change: Daily
Food: Purina Rabbit Chow; presented in measured amounts Water Type: Tap; available ad libitum
Water System: Automatic
IN-LIFE DATES: From: June 9, 1992 To: June 12, 1992
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Each test site was treated with 500 mg of test material moistened with 1.20 ml of deionized water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6: Three males and three females
- Details on study design:
- TEST SITE
- Area of exposure: 8 x 8 cm
- Type of wrap if used:
Each test site was treated with 500 mg of test material moistened with 1.20 ml of deionized water by introducing the test material beneath a surgical gauze patch measuring 2.5 x 2.5 cm and two single layers thick. Each patch was secured in place with a strip of non-irritating adhesive tape. The entire trunk of each animal was loosely wrapped with a semi-permeable dressing (orthopedic stockinette) to retard evaporation of volatile substances and to prevent possible ingestion of the test material. The wrappings were held in place with non-irritating adhesive tape. The animals were returned to their cages.
REMOVAL OF TEST SUBSTANCE
Four hours after treatment, the wrappmgs and patches were removed. The test sites were gendy wiped with a clean wet cloth to remove as much residual test material as possible.
OBSERVATION TIME POINTS
The test sites were observed for erythema and eschar formation, edema formation, and any other dermal defects or irritation at 3/4, 24, 48 and 72 hours after wiping.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The EPA 81-5 Skin irritation test showed that GU 10-415 should not be classified according to GHS criteria.
- Executive summary:
A skin irritation study (EPA 81 -5) was conducted on six albino rabbits using test material GU10-415.
There was one contact skin test site per animal. Each test site was treated with 500 mg of test material moistened with 1.20 ml of deionized water. The test sites were occluded for 4 hours. Observations for dermal irritation and defects were made at 3/4, 24, 48 and 72 hours after the occlusion period.
None of the animals showed signs of skin irritation. No signs of erythema or edema were observed. Therefore, GU10 -415 does not have to be classified according to the GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.