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EC number: 258-420-7 | CAS number: 53185-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 August 2007 - 27 September 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: "Acute swimming immobilization test in water flea" stipulated in "Order Prescribing the Tests Relating to the New Chemical Substances" (Yaku-shoku-Hatsu No. 1121002, Heisei 15.11.13 Seikyoku No.2, Kanpoki-Hatsu No. 031121002 dated November 21, 2003)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Solubility in water: ≥ 300 g/100 g
Solubility in hexane: 50 g/100 g
Stability: stable under storage conditions - Analytical monitoring:
- yes
- Details on sampling:
- - Frequency: at t=0 h and at t=48 h
- Vehicle:
- no
- Details on test solutions:
- - Preparation of test solutions: A required amount of test substance (corrected for purity 99.0%) was added to the dilution water, mixed, stirred and dissolved in a preparation vessel to prepare the test solution. The prepared test solution was divided into each replicate test vessel. The test solution was colourless and transparent at the start of the test and remained this way until the end of the exposure period.
- Control: dilution water without test substance (blank-control). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Clone A
- Source: Sheffield University, England
- Age at study initiation: < 24 hours old
- Age of parental stock (mean and range, SD): 17 days
- Feeding during test: no
ACCLIMATION
- Acclimation period: no, parent animals were cultured for over 14 days under the same conditions as used in the test
- Food during subculture period: Chlorella vulgaris, once daily, an amount corresponding to 0.1-0.2 mg C/daphnia
- Only the group that showed no mortality during the subculture period was used in the final test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 37 mg/L
- Test temperature:
- 19.8-20.0 °C during the exposure period
- pH:
- 7.8-7.9 during the exposure period
- Dissolved oxygen:
- 8.2-8.4 mg O2/L during the exposure period
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Mesured concentration: t=0: 104mg/L; t=48: 104 mg/L
The result was based on the nominal test concentration. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers, covered, fill volume approx. 100 mL
- Aeration during the test: well aerated water was used as dilution water
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Dilution water: aerated dechlorinated tap water
- Intervals of water quality measurement: dissolved oxygen concentration, pH and water temperature of the test solution were measured at the start and at the end of exposure.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light (room light)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mobility at t=24 h and t=48 h
RANGE-FINDING STUDY
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: yes, no effects were observed - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (June 2007)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - no immobility or other symptoms were observed in either the control group or the treatment groups.
- water quality parameters all remained within prescribed levels - Results with reference substance (positive control):
- - 48 h-EC50: 0.269 mg/L
- This value was within the historical range and confirmed the validity of the test system. - Validity criteria fulfilled:
- yes
- Remarks:
- Immobilisation or other adverse effects were not observed in the control group and dissolved oxygen concentrations were >3 mg/L during the exposure period.
- Conclusions:
- The 48-h EC50 of MDMPA for immobility of Daphnia magna exceeded the highest tested concentration (i.e., > 100 mg/L).
- Executive summary:
In a 48 h acute toxicity study conducted according to OECD guideline 202 and GLP principles, water fleas (Daphnia magna) were exposed to the test substance under static conditions in a limit test. The exposure concentration of 100 mg/L was varified by a sufficiently validated analytical method to be 104 mg/L at t=0 and 104 mg/L at t=48, therefore the test solution was considered to be stable in test medium and the result was based on the nominal test concentration. The incidence of immobilisation was recorded at 24 and 48 hours. No immobilisation or other effects were seen during the exposure period. Therefore, the 48h-EC50 exceeded the test concentration of 100 mg/L (i.e., was >100 mg/L). The validity criteria were met and the study is considered to be valid.
Reference
Description of key information
In a 48 h acute toxicity study conducted according to OECD guideline 202 and GLP principles, water fleas (Daphnia magna) were exposed to the test substance under static conditions in a limit test. The exposure concentration of 100 mg/L was varified by a sufficiently validated analytical method to be 104 mg/L at t=0 and 104 mg/L at t=48, therefore the test solution was considered to be stable in test medium and the result was based on the nominal test concentration. The incidence of immobilisation was recorded at 24 and 48 hours. No immobilisation or other effects were seen during the exposure period. Therefore, the 48h-EC50 exceeded the test concentration of 100 mg/L (i.e., was >100 mg/L). The validity criteria were met and the study is considered to be valid.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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