Registration Dossier
Registration Dossier
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EC number: 207-889-6 | CAS number: 499-75-2
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite (2019) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the chemical is expected to be not readily biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface (2019) prediction model was run to predict the half-life in water and sediment for the test chemical . If released in to the environment, 24.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.21%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2019). If released into the environment, 74.1% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data for the test chemical and experimental studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point and their results are summarized as below:
In the first study the Estimation Programs Interface Suite (2019) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the chemical is expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database the Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge (non-adapted) was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test chemical concentration used in the study was 100 mg/l. The percentage degradation of test chemical was determined to be 0 % by O2 consumption (BOD) parameter and 1% by both TOC removal and test material analysis by HPLC parameter in 28 days.
Next study was also reviewed from the authoritative database in this biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test chemical concentration used in the study was 100 mg/l. Test chemical undergoes 0% degradation by O2 consumption BOD parameter and 2 % degradation by both TOC removal and test material anlaysis by HPLC parameter in 28 days..
On the basis of above results for test chemical, it is concluded that the test chemical is expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (2019) prediction model was run to predict the half-life in water and sediment for the test chemical . If released in to the environment, 24.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.21%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2019). If released into the environment, 74.1% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test chemical can be considered to be not readily biodegradable in nature.
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