Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 812-526-5 | CAS number: 53831-80-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to utilise EC 202-429-0 as a read-across source. See attached document for full justification.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Study conducted in 1996. Endpoint from collected of data and compliance details are not available.
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- o-toluidine
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Not specified.
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Selenastrum capricornutum
Study design
- Test type:
- static
- Water media type:
- not specified
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Not Specified
- Test temperature:
- Not Specified
- pH:
- Not Specified
- Dissolved oxygen:
- Not Specified
- Salinity:
- Not Specified
- Conductivity:
- Not Specified
- Nominal and measured concentrations:
- Not Specified
- Details on test conditions:
- Not Specified
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- other: EbC50
- Effect conc.:
- 30.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Details on results:
- EbC50 was 30.7 mg/l (effective) after 96 hours, in a test carried out according to the OECD TG 201
towards Selenastrum capricornutum. For the endpoint growth rate an ErC50 of 110.9 mg/l was
obtained. Concentrations were measured via HPLC (CERI, 1996c).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- EbC50 was 30.7 mg/l (effective) after 96 hours, in a test carried out according to the OECD TG 201 towards Selenastrum capricornutum. For the endpoint growth rate an ErC50 of 110.9 mg/l was obtained. Concentrations were measured via HPLC (CERI, 1996c).
- Executive summary:
EbC50 was 30.7 mg/l (effective) after 96 hours, in a test carried out according to the OECD TG 201 towards Selenastrum capricornutum. For the endpoint growth rate an ErC50 of 110.9 mg/l was obtained. Concentrations were measured via HPLC (CERI, 1996c).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
