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EC number: 264-438-6 | CAS number: 63738-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 31 Jul 1980 to 14 Aug 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Version / remarks:
- in accordance with Japanese guidelines (Kapogyo No. 5, Yakuhatsu No. 615 nad 49 Kikyoku No. 392)
- Principles of method if other than guideline:
- The oxygen demand of the test substance was determined after 14 days incubation. The study is conducted as a preliminary study.
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of the test substance (as cited in study report): PGA-X
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: sludge (not further specified)
- Details on inoculum:
- - Source of sludge: Received from Chemical Biotesting Center on May 13, 1980.
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 30 mg/L
- Based on:
- test mat.
- Remarks:
- corresponds to 62.6 mg ThOD (The ThOD value was corrected to 62.6 mg by the assessor. Orginial value was 73.3 mg ThOD)
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- Biological oxygen demand (BOD)
- Details on study design:
- TEST SYSTEM
- Temperature: 25 °C
- Sludge concentration: 100 mg/L
MEASUREMENTS: O2 demand
After 14 days, the biological oxygen demand was determined using a Automatic oxygen determination system. - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1.8
- Sampling time:
- 14 d
- Remarks on result:
- other: Biodegradation value was corrected to 1.8% by the assessor. Orginial biodegradation value was 1.4% (calculated based on an incorrect ThOD-value)
- Details on results:
- The BOD of the test substance was determined to be 1.1 mg after 14 days.
- Results with reference substance:
- The degree of biodegradation of the reference substance after 7 days was 70.7 %.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Supplementary estimation of ready biodegradability using BIOWIN v4.10
- Principles of method if other than guideline:
- BIOWIN v4.10 prediction for readily biodegradation.
- GLP compliance:
- no
- Specific details on test material used for the study:
- - SMILES: C3OC3CN(CC4CO4)Cc1cccc(CN(CC5CO5)CC2CO2)c1
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- Biowin2 (Non-Linear Biodeg Probability)
- Value:
- 0
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- Substance does not fall within the applicability domain of the model.
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks:
- Biowin6 (MITI Non-Linear Biodeg Probability)
- Value:
- 0.001
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- Substance does not fall within the applicability domain of the model.
- Details on results:
- A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable - Interpretation of results:
- not readily biodegradable
Referenceopen allclose all
Endpoint |
Result |
Biowin1 (Linear Model Prediction) |
Does Not Biodegrade Fast |
Biowin2 (Non-Linear Model Prediction) |
Does Not Biodegrade Fast |
Biowin3 (Ultimate Biodegradation Timeframe) |
Months |
Biowin4 (Primary Biodegradation Timeframe) |
Weeks-Months |
Biowin5 (MITI Linear Model Prediction) |
Not Readily Degradable |
Biowin6 (MITI Non-Linear Model Prediction) |
Not Readily Degradable |
Biowin7 (Anaerobic Model Prediction) |
Does Not Biodegrade Fast |
Ready Biodegradability Prediction |
NO |
The test substance does not fall within the applicability domain of the model as the number of some fragments exceeds the maximum number of fragments identified within the training set (Appendix D of the On-Line BIOWIN(TM) User's Guide).
Please refer to the full results report attached to this IUCLID record.
Description of key information
The test substance was determined to be not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The biodegradation potential of the substance in water was determined in a non-GLP preliminary screening study similar to OECD TG 301C (Modified MITI Test) (Niigata Research Laboratory, 1980). In this study, 30 mg/L test substance was inoculated with sludge for 14 days under aerobic conditions. During the incubation period the biological oxygen demand (BOD) was measured and thereafter compared to the theoretical uptake (ThOD), to determine the degree of biodegradation. After the 14-day incubation period 1.8% of the substance was biodegraded. Although the test substance was not incubated for the prescribed 28 days, a worst-case conclusion is drawn based on 14 days incubation that the substance is not readily biodegradable.
To support this outcome, BIOWIN v4.10 data was generated on the test substance as part of a weight-of-evidence approach. The QSAR model predicts that the substance is not readily biodegradable. Even though the substance does not (completely) fall within the applicable domain, the results can still be used to support the study results. Therefore, the substance is considered not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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