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Diss Factsheets
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EC number: 200-959-7 | CAS number: 76-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
4.1. Description of first aid measures:
IN CASE OF INGESTION:
Measures:
- Do not give the victim anything to eat or drink, and do not induce vomiting if the victim is unconscious.
- Induce vomiting immediately as directed by medical personnel.
IN CASE OF INHALATION:
Measures:
- Take the victim into fresh air, loosen his clothes and let him rest.
- If not breathing, give artificial respiration.
- If breathing is difficult, give oxygen.
- Obtain medical help.
IN CASE OF SKIN CONTACT:
Measures:
- Remove the contaminated clothes and shoes!
- Immediately wash the contaminated area with plenty of water and soap (for 15 minutes)!
- Obtain immediate medical help.
- Wash clothing before reuse.
IN CASE OF EYE CONTACT:
Measures:
- In case of contact with eyes flush immediately with plenty of flowing water for 15 minutes holding eyelids apart (for at least 15
minutes)!
- Obtain immediate medical help.
4.2. Most important symptoms and effects, both acute and delayed:
Inhalation: no data available.
Ingestion: Narcotic. May cause (in order of increasing dose) lightheadedness, nausea, vomiting, sedation, constipation, constricted
pupils (miosis), sweating, respiratory depression, and circulatory collapse.
In case of skin contact: not expected to cause health effects, although the possibility of absorption exists under conditions of skin
breakage or inflammation.
Eye Contact: Mild irritant but will also have a strong narcotic effect (pupil constriction) and the eye may serve as an absorption
route to the body in general.
Chronic Exposure:
Caution, may be habit forming. Chronic exposure may lead to tolerance, dependence, and unpleasant withdrawal symptoms upon
abrupt discontinuation of use (e.g., sweating, restlessness, irritability, hallucinations).
Aggravation of Pre-existing Conditions:
Some individuals may become sensitized from exposure and develop skin rashes, coughs, stuffy nose, asthma, and other allergic
complaints. Sensitivity may develop soon after immediate contact or after years of exposure. Note: While there are no reports
directly linking this material to allergic reactions, several other compounds form this chemical category have been associated with
skin and respiratory allergic reactions associated with occupational exposure.
4.3. Indication of any immediate medical attention and special treatment needed:
No data available.
Fire-fighting measures
5.1. Extinguishing media:
5.1.1. Suitable extinguishing media:
Water fog, alcohol resistant foam, dry chemical, carbon dioxide.
5.1.2. Unsuitable extinguishing media:
None known.
5.2. Special hazards arising from the substance or mixture:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion
hazard.
5.3. Advise for fire fighters
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece
operated in the pressure demand or other positive pressure mode. Follow handling guidance appropriate for OEB-3 potent
compounds,
Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures:
6.1.1 For non-emergency personnel:
Keep unprotected people away, allow only well trained experts wearing suitable protective clothing to abide in the field of
accident.
6.1.2. For emergency responders:
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in
Section 8, and follow handling guidance appropriate for OEB-3 potent compounds, (see Section 7). Isolate hazard area. Keep
unnecessary and unprotected personnel from entering. All clean-up operations should be witnessed by more than one individual.
6.2. Environmental precautions:
Dispose of spillage and waste (product/packaging) in accordance with all applicable environmental laws. Do not allow to enter
sewers/soil/surface or ground water. Notify the respective authorities in accordance with local law in the case of environmental
pollution immediately.
6.3. Methods and material for containment and cleaning up:
Carefully sweep up material into an appropriate container and save for reclamation or disposal. Use non-sparking tools and
equipment. Do not flush to sewer! The amount of material collected should be assessed and documented.
Handling and storage
7.1. Precautions for safe handling:
Precautions for safe handling:
Observe conventional hygiene precautions.
Use appropriate protective equipment.
Technical measures:
To prevent contamination and overexposure, no open handling of powder should be allowed. Powder handling operations are to
be done in a powders weighing hood, a glove box, or other equivalent ventilated containment system. In situations where these
ventilated containment hoods have not been installed, a non-ventilated enclosed containment hood should be used. Pending
changes resulting from additional air monitoring data, up to 300 mg can be handled outside of an enclosure provided that no
grinding, crushing or other dust-generating process occurs.
Precautions against fire and explosion:
No specific prescription.
7.2. Conditions for safe storage, including any incompatibilities:
Technical measures and storage condition:
Keep in a tightly closed container, stored in a cool, dry, ventilated area.
Protect from physical damage and direct sunlight.
Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings
and precautions listed for the product.
Oxymorphone has potent pharmacological activity and is classified as an OEB-3* material.
Incompatible materials: Alkalis, tannin, strong oxidizing agents, borax, ferric chloride, iodides, lead acetate, mercuric chloride,
gold salts.
Packaging material: no special prescriptions.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- none
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
8.2. Exposure controls:
In case of a hazardous material with no controlled concentration limit it is the employer’s duty to keep concentration levels down
to a minimum achievable by existing scientific and technological means, where the hazardous substance poses no harm to workers.
8.2.1 Appropriate engineering controls:
In pursuance of work is proper foresight needed to avoid spilling onto clothes and floors and to avoid contact with eyes and skin.
Ventilation System: to prevent contamination and overexposure, no open handling of powder should be allowed. Powder handling
operations are to be done in a powders weighing hood, a glove box, or other equivalent ventilated containment system. In
situations where these ventilated containment hoods have not been installed, a non-ventilated enclosed containment hood should
be used. Pending changes resulting from additional air monitoring data, up to 300 mg can be handled outside of an enclosure
provided that no grinding, crushing or other dust-generating process occurs.
Allergic responses in sensitive individuals will disappear if removed from exposure.
Maintain eye wash fountain and quick-drench facilities in work area.
8.2.2. Individual protection measures, such as personal protective equipment:
1. Eye/face protection: use appropriate chemical safety goggles.
2. Skin protection:
a. Hand protection: use appropriate protective gloves.
b. Other: wear appropriate clean body-covering clothing.
3. Respiratory protection: See Section 7 for information on proper handling and specific respirator recommendations for potent
compounds.
4. Thermal hazard: None known.
8.2.3. Environmental exposure controls:
No specific prescription.
Stability and reactivity
10.1. Reactivity:
None known.
10.2. Chemical stability:
At normal temperature and general conditions of work stabile.
10.3. Possibility of hazardous reactions
Hazardous polymerisation will not occur.
10.4. Conditions to avoid
Discolours on exposure to light.
10.5. Incompatible materials:
Alkalis, tannin, strong oxidizing agents, borax, ferric chloride, iodides, lead acetate, mercuric chloride, gold salts.
10.6. Hazardous decomposition products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Disposal considerations
13.1. Waste treatment methods:
Disposal according to the local regulations.
13.1.1. Information regarding the disposal of the product:
Processing, use or contamination of this product may change the waste management options State and local disposal regulations
may differ from federal disposal regulations. Follow handling guidance appropriate for OEB-3 potent compounds, (see Section
7).
During the disposal of the product, its residue and its packaging the national and local prescriptions should be observed. The EWC
codes indicated below are only recommendations, but they may have to be changed due to special circumstances, in such cases new
classification may be needed.
13.1.2. Information regarding the disposal of the packaging:
Dispose of container and unused contents in accordance with federal, state and local requirements.
13.1.3. Physical/chemical properties that may affect waste treatment options shall be specified:
None known.
13.1.4. Sewage disposal:
None known.
13.1.5. Special precautions for any recommended waste treatment:
No data available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.