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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Limited data are available to evaluate the acute toxicity of PEG-4 dimethacrylate.

Based on these data, the oral LD50 value in the rat was >5000 mg/kg, and the dermal LD50 value in rat was > 3000 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
The oral LD50 of the substance has been determined to evaluate the potential acute toxicity.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes
Species:
rat
Route of administration:
oral: gavage
Doses:
5000 mg/kg
Control animals:
no
Details on study design:
no details
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
The oral LD50 value of PEG-4 Dimethacrylate in the rat was >5000 mg/kg.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
The data is considered to be reliable.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
The dermal LD50 of the substance has been determined to evaluate the potential of acute toxicity.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes
Species:
rat
Type of coverage:
not specified
Doses:
3000 mg/kg
Control animals:
not required
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Interpretation of results:
GHS criteria not met
Conclusions:
The dermal LD50 value of PEG-4 Dimethacrylate in the rabbits was > 3000 mg/kg.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
3 000 mg/kg bw
Quality of whole database:
The data is considered to be reliable.

Additional information

Based on these publication of Andrews (1986), PEG-4 dimethacrylate showed an oral LD50 value in the rat higher than 5000 mg/kg, and a dermal LD50 value in rat higher than 3000 mg/kg.

A supporting study is available on an analogue by oral route.

In a pre-guideline acute oral toxicity study, groups of fasted male and female SPF Wistar rats were given a single oral dose of Ethylene glycol dimethacrylate > 98.5 % at doses of 7.94, 8.89, 10.00, 11.20 and 12.60 ml/kg bw and observed for 14 days. Oral LD50 Combined = 8.30 ml/kg bw equals ca. 8700  mg/kg bw. Ethylene glycol dimethacrylate is of very low oral toxicity based on this LD50 test in males and females.

Justification for classification or non-classification

Based on the available data, no classification for acute toxicity is required for PEG-4 dimethacrylate according to the Regulation EC n°1272/2008.