Glucosidase, β-

GHS

General Information

Name:

B-Glucosidase

Implementation:

EU

Type of classification:

harmonised classification

Remarks:

Harmonised classification in accordance with Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation).

Enzymes possess respiratory sensitization potential regardless of the catalytic activities. Enzymes must therefore be classified as “H334: Hazard Category 1: May cause allergy or asthma symptoms or breathing difficulties if inhaled” in accordance with the CLP Regulation. The threshold concentration for classification and labelling with pictogram is 1 % (per individual enzyme), and for allergy warning is 0.1%, based on active enzyme protein (aep).

According to Guidance for identification and naming of substances in REACH (Section 4.3.2.3), enzyme substances are identified by:

a.    the catalytic activity of the enzyme protein (IUBMB nomenclature; active enzyme protein) and

b.    the other constituents from the fermentation (other proteins + peptides and amino acids; carbohydrates; lipids; inorganic salts).

Active enzyme protein (aep): The active enzyme protein (aep) is a potential respiratory sensitizer characterized by the catalytic activity as the main identifier

Other proteins + peptides and amino acids:

In general, each individual protein within the “Other proteins” constituent will not be present in concentrations above 1 %.

This constituent is mainly composed of denatured and inactivated enzyme proteins as well as peptides and amino acids. These are not a risk factor under the exposure conditions of industrial enzymes.  

Carbohydrates,  Lipids and Inorganic salts

The carbohydrates, lipids and inorganic salts which are present in the dry matter of an enzyme concentrate are not respiratory sensitizing substances.

Related composition

Related composition:

B-Glucosidase

B-Glucosidase

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data conclusive but not sufficient for classification

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Reason for no classification:

data conclusive but not sufficient for classification

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Hazard category:

Resp. Sens. 1

Hazard statement:

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin sensitisation

Reason for no classification:

data conclusive but not sufficient for classification

Aspiration hazard

Reason for no classification:

data conclusive but not sufficient for classification

Reproductive toxicity

Reason for no classification:

data conclusive but not sufficient for classification

Effects on or via lactation

Reason for no classification:

data conclusive but not sufficient for classification

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data conclusive but not sufficient for classification

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Reason for no classification:

data conclusive but not sufficient for classification

Hazardous to the aquatic environment (long-term)

Reason for no classification:

data conclusive but not sufficient for classification

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Danger

Hazard pictogram

GHS08: health hazard

Hazard statements

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Precautionary statements

P261: Avoid breathing dust/fume/gas/mist/vapours/spray.

P284: [In case of inadequate ventilation] wear respiratory protection.

In case of inadequate ventilation wear respiratory protection.

P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER/doctor/…

P501: Dispose of contents/container to ...

Dispose of waste according to applicable legislation.