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EC number: 281-876-3 | CAS number: 84051-87-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Eye Irritation:
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Weight of evidence approach based on various test chemicals
- Justification for type of information:
- Weight of evidence approach based on various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence approach based on various test chemicals
- Principles of method if other than guideline:
- Weight of evidence approach based on various test chemicals
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other: 1. undiluted; 2. water; 3. water
- Controls:
- not specified
- Amount / concentration applied:
- 1. 0.5 ml
2. 500 mg of the test chemical was moistened with water at after removal of the patches.
3. 0.5 g of the test chemical moistened with water - Duration of treatment / exposure:
- single
- Observation period:
- 1. 24 and 72 hours
2. 1, 24, 48 and 72 hours
3. at 1, 24, 48 and 72 hours - Number of animals:
- 1. 6
2. 3
3. 3 - Details on study design:
- The data is based on weight of evidence approach based on various test chemicals
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".- Executive summary:
The skin irritation potential of the test chemical was assessed based on the available results from the various test chemicals.
The dermal irritation potential of the test chemical was assessed in rabbits.0.5 ml of semi permanent dye containing 0.38% (wt/wt) test chemical was applied to the intact skin of 6 rabbits and observed for signs of irritation. The dermal reactions were observed and scored at 24 and 72 hours. The maximum score for dermal reactions was 4.
No signs of irritation were noted on the rabbit skin. The primary irritation index was reported to be 0.0.
Based on the scores and observations, the test chemical can be considered not irritating to rabbit skin.
This is supported by the results of a study performed on rabbits in accordance with OECD 404 Guidelines to determine the degree of irritation caused by the test chemical. The study was performed One day prior to the application of the test chemical, the dorsal area of the trunk of 3 female New Zealand White rabbits was clipped free of fur. 500 mg of the test chemical was moistened with water was applied clipped skin of 3 rabbits under semi-occlusive conditions for 4 hours. Subsequently, the dressings were removed, any residual test substance was wiped off. The skin was examined for erythema, eschar formation and edema at 1, 24, 48 and 72 hours after removal of the patches.
No signs of irritation were noted on the rabbit skin.Brown/yellow skin discolouration was observed at the 1-hour time-point but did not prevent the accurate assessment of erythema.
Based on the observations, the test chemical can be considered not irritating to rabbit skin.
The above studies are supported by the results of a study performed on rabbits in accordance with OECD 404 and 92/69/EEC. Annex V Guidelines to assess the dermal irritation potential of the test chemical was assessed in rabbits. 0.5 g of the test chemical moistened with water was applied to 6.25 cm² area of intact skin of 3 female New Zealand albino rabbits under semi-occlusive conditions for 4 hours. Remaining test substance was removed by swabbing with cotton wool swabs soaked in warm water.The skin was examined for erythema, eschar formation and edema at 1, 24, 48 and 72 hours after removal of the patches. An index of Cutaneous Primary Irritation was calculated from the mean scores at the sites and at each time point. No signs of irritation were noted on the rabbit skin. Red/orange staining was reported at all time points. The primary irritation index was reported to be 0.0.
Based on the scores and observations, test chemical can be considered not irritating to rabbit skin.
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Weight of evidence approach based on test chemicals
- Justification for type of information:
- Weight of evidence approach based on test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Weight of evidence approach based on test chemicals
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 1. 100 mg
2. undiluted 100mg - Duration of treatment / exposure:
- single
- Observation period (in vivo):
- 1. 1, 2, 3, and 7 days
2. no data available - Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 1. 6
2. no data available - Details on study design:
- The data is based on weight of evidence approach based on various test chemicals
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no signs of irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- By applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
- Executive summary:
The eye irritation potential of the test chemical was assessed based on the available results from the various test chemicals.
The ocular irritation potential of the test chemical was assessed in rabbits. 100 mg of the powdered dye was instilled in one eye of 6 rabbits and the other eye served as control. The treated eyes were observed and scored at 1, 2, 3, and 7 days. The maximum attainable score was 110.
No signs of irritation were observed in the treated eyes of rabbits at any time point.
The scores obtained at 1, 2, 3, and 7 days were 0.0. Hence, the test chemical can be considered to be not irritating to rabbit eyes.
This is supported by the results of an ocular irritation study of the test chemical conducted on rabbits to assess the eye irritancy of test chemical.
Undiluted 100mg of test chemical was installed into the eye of each rabbits which produced Slight conjunctival changes only after one hour.
Since the observed effects were cleared, the test chemical was considered to be not irritating to the rabbits’ eye.
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
The skin irritation potential of the test chemical was assessed based on the available results from the various test chemicals.
The dermal irritation potential of the test chemical was assessed in rabbits.0.5 ml of semi permanent dye containing 0.38% (wt/wt) test chemical was applied to the intact skin of 6 rabbits and observed for signs of irritation. The dermal reactions were observed and scored at 24 and 72 hours. The maximum score for dermal reactions was 4.
No signs of irritation were noted on the rabbit skin. The primary irritation index was reported to be 0.0.
Based on the scores and observations, the test chemical can be considered not irritating to rabbit skin.
This is supported by the results of a study performed on rabbits in accordance with OECD 404 Guidelines to determine the degree of irritation caused by the test chemical. The study was performed One day prior to the application of the test chemical, the dorsal area of the trunk of 3 female New Zealand White rabbits was clipped free of fur. 500 mg of the test chemical was moistened with water was applied clipped skin of 3 rabbits under semi-occlusive conditions for 4 hours. Subsequently, the dressings were removed, any residual test substance was wiped off. The skin was examined for erythema, eschar formation and edema at 1, 24, 48 and 72 hours after removal of the patches.
No signs of irritation were noted on the rabbit skin. Brown/yellow skin discolouration was observed at the 1-hour time-point but did not prevent the accurate assessment of erythema.
Based on the observations, the test chemical can be considered not irritating to rabbit skin.
The above studies are supported by the results of a study performed on rabbits in accordance with OECD 404 and 92/69/EEC. Annex V Guidelines to assess the dermal irritation potential of the test chemical was assessed in rabbits. 0.5 g of the test chemical moistened with water was applied to 6.25 cm² area of intact skin of 3 female New Zealand albino rabbits under semi-occlusive conditions for 4 hours. Remaining test substance was removed by swabbing with cotton wool swabs soaked in warm water. The skin was examined for erythema, eschar formation and edema at 1, 24, 48 and 72 hours after removal of the patches. An index of Cutaneous Primary Irritation was calculated from the mean scores at the sites and at each time point.
No signs of irritation were noted on the rabbit skin. Red/orange staining was reported at all time points. The primary irritation index was reported to be 0.0.
Based on the scores and observations, test chemical can be considered not irritating to rabbit skin.
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Eye Irritation
The eye irritation potential of the test chemical was assessed based on the available results from the various test chemicals.
The ocular irritation potential of the test chemical was assessed in rabbits. 100 mg of the powdered dye was instilled in one eye of 6 rabbits and the other eye served as control. The treated eyes were observed and scored at 1, 2, 3, and 7 days. The maximum attainable score was 110.
No signs of irritation were observed in the treated eyes of rabbits at any time point.
The scores obtained at 1, 2, 3, and 7 days were 0.0. Hence, the test chemical can be considered to be not irritating to rabbit eyes.
This is supported by the results of an ocular irritation study of the test chemical conducted on rabbits to assess the eye irritancy of test chemical.
Undiluted 100mg of test chemical was installed into the eye of each rabbits which produced Slight conjunctival changes only after one hour.
Since the observed effects were cleared, the test chemical was considered to be not irritating to the rabbits’ eye.
By applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Comparing the annotations with criteria of CLP regulation, the test chemical can be classified under the category "Not Classified".
Justification for classification or non-classification
The results of the experimental studies from the various test chemicals indicate a possibility that the test chemical can be not irritating to skin and eyes.
Hence, by applying the weight of evidence approach,the test chemical can be considered to be not irritating to skin and eyes. It can be classified under the category “Not Classified” as per CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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