Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-621-2 | CAS number: 2835-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute toxicity of the substance 4-amino-m-cresol to Fish, Daphnia and Algae was tested according to OECD guidelines and GLP. These tests are considered as reliable (Klimisch 1) and the obtained results are expressed on measured concentrations :
- 96h-LC50/Zebrafish = 0.42 mg/L based on time-weighted mean measured concentration (OECD 236),
- 48h-EC50/Daphnia magna = 0.20 mg/L based on time-weighted mean measured concentration (OECD 202),
- 72h-EC50_growth rate/ Pseudokirchneriella subcapitata = 0.035 mg/L based on geometric mean measured concentrations (OECD 201).
Other acute tests on fish, daphnia and algae were also performed on the degradation products of the substance 4-amino-m-cresol (after ~20 hours aging period). These tests were considered of poor reliability (Klimisch 3) because no analysis was performed. Higher LC50 or EC50 were observed (lower toxicity to Fish, Daphnia and Algae) than in the above reported results.
A chronic toxicity test on Daphnia was also performed according to the guideline OECD 211 and GLP. The NOEC for adult survival, time of the first brood and juveniles produced per surviving parent, and adult growth are equal to 0.22 mg/L based on time-weighted mean measured concentrations, in this 21-day Daphnia magna reproduction study.
The algae Pseudokirchneriella subcapitata are the most sensitive species in chronic tests with a 72h-EC10_growth rate equal to 0.0098 mg/L based on geometric mean measured concentrations.
The validity criteria were within the acceptable range according to the OECD guidelines for these 2 tests and they were both considered as Klimisch 1.
The substance 4-amino-m-cresol was also tested on activated sludge according to OECD 209 guideline and GLP. 4-amino-m-cresol has an inhibitory effect on the respiration of activated sludge with 3 hour EC50 as 32.3 mg/L, based on nominal concentration.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.