Registration Dossier
Registration Dossier
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EC number: 250-654-8 | CAS number: 31482-56-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 September 2017 to 9 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Method A.24. “Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method”
- Version / remarks:
- Commission Regulation (EU) No 2016/266 of 7 December 2015 amending, for the purpose of its adaptation to technical progress, the Annex to Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Method A.24. “Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method”, Official Journal of the European Union L 54 of 01 March 2016
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.38
- Temp.:
- 25 °C
- Remarks on result:
- other: no data on pH
- Details on results:
- The capacity factor k and log Pow for the test material were calculated based on the calibration data obtained with the reference substances. The estimated log Pow: 4.38 ± 0.001 (with 95 % confidence interval).
- Conclusions:
- Under the conditions of the study, the log Pow of the test material was 4.38 ± 0.001.
- Executive summary:
The partition coefficient of the test material was determined in line with standardised guidelines EU Method A.24 nd OECD 117, under GLP conditions, using the HPLC method.
Under the conditions of the study, the low Pow of the test material was determined to be 4.38 ± 0.001.
Reference
Measured and calculated data of test material
| log k | log Pow | Pow | ||
| Retention time (min) | Calculated data | |||
| Test material | 14.48 | 0.862 | 4.38 | 23907 |
| 14.48 | 0.862 | 4.38 | 23907 | |
| 14.47 | 0.861 | 4.38 | 23839 | |
| 14.49 | 0.862 | 4.38 | 23975 | |
| 14.48 | 0.862 | 4.38 | 23907 | |
| 14.48 | 0.862 | 4.38 | 23907 | |
| Mean | 14.48 | 0.862 | 4.38 | 23907 |
| C.I. (95%) | 0.001 | |||
| CV (%) | 0.0 | |||
Description of key information
Under the conditions of the study, the log Pow of the test material was 4.38 ± 0.001
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.38
- at the temperature of:
- 25 °C
Additional information
The partition coefficient of the test material was determined in line with standardised guidelines EU Method A.24 nd OECD 117, under GLP conditions, using the HPLC method.
Under the conditions of the study, the low Pow of the test material was determined to be 4.38 ± 0.001.
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