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EC number: 911-168-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August from 03 to 10, 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- The acute lethal toxicity of the test substance to Leuciscus idus f. melanotus was investigated under static exposure conditions over a period of 96 hours. 10 fish were exposed to one of the following nominal dose levels: 0, 1, 10, 100 and 500 mg/l .No chemical analysis of the test substance concentration was conducted.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- Leuciscus idus melanotus
- Details on test organisms:
- TEST ORGANISM
- Common name: goldorfe.
- Source: Paul Eggers, 2354 Hohenwestedt.
- Length at study initiation: 3.5 - 4.4 cm (mean = 3.9 cm; s = 0.2 g; n = 50).
- Weight at study initiation: 0.7 - 1.2 g (mean = 0.88 g; s = 0.13 g; n = 50).
ACCLIMATION
- Acclimation period: the fish were adapted to the experimental conditions at least 14 days prior to the experiment. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 20 ± 0.5 °C
- Nominal and measured concentrations:
- 0, 1, 10, 100 and 500 mg/l nominal.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: full-glass aquariums, 40 × 25 × 30 cm.
- Volume: 20 litres.
- No. of organisms per vessel: 10.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: chlorinated tap water, treated with activated carbon filter.
- Total hardness: 17.8°dH; carbonate hardness 12°dH.
- pH: 7.8
OTHER TEST CONDITIONS
- Photoperiod: 12 hours of light and 12 of darkness.
- Light intensity: 700 Lux.
EFFECT PARAMETERS MEASURED
During the whole experiment, the fish were regularly observed and the behavior recorded.
The surviving fish was sacrificed after the end of the experiment and macroscopically examined.
The oxygen content and the pH values were checked at the beginning of the experiment and after 24-hour intervals. - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Over the whole exposure period, no fish died in none of the concentration group.
The behavior was unaffected in all experimental groups and did not differ from that of the control fish. The section of the fish slaughtered at the end of the experiment revealed yellow-discolored intestinal contents in all experimental groups. - Conclusions:
- LC50 (96h) > 500 mg/l (nominal)
- Executive summary:
The acute lethal toxicity of test substance to Leuciscus idus f. melanotus was investigated under static exposure conditions over a period of 96 hours. 10 fish were exposed to each one of the follwoing nominal dose levels: 0, 1, 10, 100 and 500 mg/l. No chemical analysis of the test substance concentrations was conducted.
Over the whole exposure period, no fish died in none of the concentration groups. The behavior was unaffected in all experimental groups and did not differ from that of the control fish. The section of the fish slaughtered at the end of the experiment revealed yellow-discolored intestinal contents in all experimental groups.
Conclusion
LC50 (96h) > 500 mg/l (nominal)
Reference
Description of key information
Not harmful/toxic to fish, after short-term exposure.
Key value for chemical safety assessment
Additional information
The acute lethal toxicity of the Fluorescent Brightener 219 was assessed in Leuciscus idus f. melanotus, under static exposure conditions. Fish were exposed to the following nominal dose levels: 0, 1, 10, 100 and 500 mg/l; no chemical analysis of the test substance concentrations was conducted. Over the whole exposure period of 96 hours, no fish died in none of the concentration groups. The behavior was unaffected in all experimental groups and did not differ from that of the control fish. The section of the fish slaughtered at the end of the experiment revealed yellow-discolored intestinal contents in all experimental groups.
In order to support the study outcomes, available data on one of the substance constituents (i.e. constituent 2) has also been taken into consideration. The acute lethal toxicity of the substance was investigated on guppy, under static exposure conditions over a period of 96 h. The only applied nominal test concentration was 100 mg/l. Due to the limited water solubility of the test material the respective amount was added as an acetonic solution to the empty test vessel. After complete evaporation of the solvent, the test water was added. No chemical analysis of the test substance concentration was conducted. At the nominal concentration of 100 mg/l one of a total of seven fish died after 96h of exposure. Other toxic effects than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed.
The no-observed-effect concentration (NOEC) was higher than 100 mg/l since the one fish that died is considered not to represent a significant effect as defined by the validity criteria of the test.
In both the cases, no acute adverse effects were recorded at the highest tested dosages; thus, the substance resulted to be not harmful/toxic to fish, after short-term exposure.
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