Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-266-0 | CAS number: 7803-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentiioned below
- Principles of method if other than guideline:
- WoE report is based on three short term toxicity to aquatic invertebrate studies as-
WoE 2., WoE 3 and WoE 4. - GLP compliance:
- not specified
- Analytical monitoring:
- no
- Remarks:
- WoE 2 & WoE 4: no and WoE 3: no specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2 & WoE 3: Daphnia magna and WoE 4: Branchiura sowerbyi (other aquatic worms)
- Details on test organisms:
- WoE 2:
TEST ORGANISM
- Common name: Water flea
WoE 3:
TEST ORGANISM
- Common name: Water flea
- Source: Test organism culture was originally obtained from Put-In-Bay, Ohio.
- Maintenance: Test organism were cultured in the laboratory.
WoE 4:
TEST ORGANISM
- Common name: Oligochaete - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- WoE 2: 48 hrs and WoE 3 & WoE 4: 96 hrs
- Hardness:
- WoE 2 and WoE 3: no data available
WoE 4: 220 mg/l as CaCO3 - Test temperature:
- WoE 2 and WoE 3: no data available
WoE 4: 36°C - pH:
- WoE 2 and WoE 3: no data available
WoE 4: 7.5 - Dissolved oxygen:
- WoE 2 and WoE 3: no data available
WoE 4: 7.5 mg/l - Details on test conditions:
- WoE 2: no data available
WoE 3:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Standard reference water (SRF) obtained from University Lake which was then filtered through glass wool.
- Other: Standard reference water was described as a laboratory prepared medium which is free from organisms and contains all the major ions in concentrations and proportions of a mean surface water of the United States.
WoE 4:
TEST MEDIUM / WATER PARAMETERS
- Alkalinity: 170 mg/l as CaCO3 - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 940 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: WoE 2
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 940 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: WoE 2
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 423 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: WoE 3
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 433 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: WoE 3
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 292 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: WoE 3
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: WoE 4
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: WoE 4
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the comparatively similar read across chemical and applying the weight of evidence approach, the 48 hr EC50/LC50 value of the test chemical on test organism can be expected to be in the range 433 to > 1200 mg/l.
- Executive summary:
Data available for the comparatively similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on aquatic invertebrates. The studies are as mentioned below:
Short term toxicity to aquatic invertebrate study was conducted for 48 hrs for assessing the effect of test chemical. The study was performed in accordance with the ISO 6341 15 "Water quality – Determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea)" in a static system. Daphnia magna was used as a test organism. Test chemical concentrations were not verified analytically. On the basis of effect of test chemical on the mobility of the test organism Daphnia magna, the 48 hr EC0 and EC50 value was determined to be 940 mg/l and > 940 mg/l (nominal concentration).
Another short term toxicity to aq. Invertebrate study was conducted for 96 hrs for assessing the effect of test chemical. Study was performed in a static system using Daphnia magna as a test organism. Test organism was originally obtained from Put-In-Bay, Ohio and cultured in the laboratory. Standard reference water (SRF) obtained from University Lake which was then filtered through glass wool was used as a test medium. It is free from organisms and contains all the major ions in concentrations and proportions of a mean surface water of the United States. On the basis of effect on mortality of the test organism Daphnia magna, the 24, 48 and 96 hr LC50 value was determined to be 423, 433 and 292 mg/l.
For the test chemical, short term toxicity to Branchiura sowerbyi (Oligochaete) study was conducted for 96 hrs for assessing the effect of test chemical. No analytical monitoring was performed of exposed test chemical concentrations. This test was performed under static conditions at a temperature of 36°C, pH 7.5, dissolved oxygen of 7.5 mg/l, hardness of 220 mg/l as CaCO3 and alkalinity 170 mg/l as CaO3.On the basis of effect on mortality of the test organism Branchiura sowerbyi, the 96 hr LC50 was determined to be 1200 mg/l. It would be generally expected that the LC50 at short time period should be greater than the LC50 obtained in the longer time period. Thus, the 48 LC50 value can be evaluated to be > 1200 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the 48 hr EC50/LC50 value of the test chemical on test organism can be expected to be in the range 433 to > 1200 mg/l. Based on this value, test chemical was considered as non-toxic to aquatic invertebrates and hence, considered to be not classified as per the CLP classification criteria.
Reference
WoE 2: no data available
WoE 3:
Table: Median tolerance limit of test chemical for Daphnia magna in dilution media.
Chemical |
Test organism |
Medium |
TLm (mg/l) |
|||
24 hr |
48 hr |
72 hr |
96 hr |
|||
Test chemical |
Daphnia magna |
Standard reference water (SRF) |
423* |
433* |
- |
292* |
WoE 4: no data available
Description of key information
On the basis of the experimental studies of the comparatively similar read across chemical and applying the weight of evidence approach, the 48 hr EC50/LC50 value of the test chemical on test organism can be expected to be in the range 433 to > 1200 mg/l.
Key value for chemical safety assessment
Additional information
Data available for the comparatively similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on aquatic invertebrates. The studies are as mentioned below:
Short term toxicity to aquatic invertebrate study was conducted for 48 hrs for assessing the effect of test chemical. The study was performed in accordance with the ISO 6341 15 "Water quality – Determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea)" in a static system. Daphnia magna was used as a test organism. Test chemical concentrations were not verified analytically. On the basis of effect of test chemical on the mobility of the test organism Daphnia magna, the 48 hr EC0 and EC50 value was determined to be 940 mg/l and > 940 mg/l (nominal concentration).
Another short term toxicity to aq. Invertebrate study was conducted for 96 hrs for assessing the effect of test chemical. Study was performed in a static system using Daphnia magna as a test organism. Test organism was originally obtained from Put-In-Bay, Ohio and cultured in the laboratory. Standard reference water (SRF) obtained from University Lake which was then filtered through glass wool was used as a test medium. It is free from organisms and contains all the major ions in concentrations and proportions of a mean surface water of the United States. On the basis of effect on mortality of the test organism Daphnia magna, the 24, 48 and 96 hr LC50 value was determined to be 423, 433 and 292 mg/l.
For the test chemical, short term toxicity to Branchiura sowerbyi (Oligochaete) study was conducted for 96 hrs for assessing the effect of test chemical. No analytical monitoring was performed of exposed test chemical concentrations. This test was performed under static conditions at a temperature of 36°C, pH 7.5, dissolved oxygen of 7.5 mg/l, hardness of 220 mg/l as CaCO3 and alkalinity 170 mg/l as CaO3.On the basis of effect on mortality of the test organism Branchiura sowerbyi, the 96 hr LC50 was determined to be 1200 mg/l. It would be generally expected that the LC50 at short time period should be greater than the LC50 obtained in the longer time period. Thus, the 48 LC50 value can be evaluated to be > 1200 mg/l.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the 48 hr EC50/LC50 value of the test chemical on test organism can be expected to be in the range 433 to > 1200 mg/l. Based on this value, test chemical was considered as non-toxic to aquatic invertebrates and hence, considered to be not classified as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.