Registration Dossier
Registration Dossier
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EC number: 215-363-2 | CAS number: 1324-11-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 - 10 Dec 1977
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FDA Guideline
- Version / remarks:
- 1973
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- dibromodibenzo[b,def]chrysene-7,14-dione
- EC Number:
- 215-363-2
- Cas Number:
- 1324-11-4
- Molecular formula:
- C24H10Br2O2
- IUPAC Name:
- dibromodibenzo[b,def]chrysene-7,14-dione
- Test material form:
- solid
- Details on test material:
- Vat Orange 1
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Robert Koch OHG, Hamm, Germany
- Age at study initiation: ca 3-5 months
- Weight at study initiation: 1.5 - 2.0 kg
- Housing: single
- Diet: Altromin 2123 ad lib.
- Water (ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 50 ± 20 %
- Air changes (per hr): -
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 25 cm²
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lukewarm tap water
- Time after start of exposure: after 4 hours
SCORING SYSTEM: Draize
24, 48 and 72 hours after removal of the test substance
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- orange discolouration of skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Erythema could not be assessed properly due to orange discolouration of skin caused by the substance. Slight signs of irritation were fully reversible within the observation period. No signs of corrosion observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was not found to be irritating or corrosive on rabbit skin.
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