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EC number: 307-988-5 | CAS number: 97808-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
- Reference Type:
- publication
- Title:
- Acute oral toxiciry study in rats
- Author:
- Ronald et al.
- Year:
- 1 984
- Bibliographic source:
- Toxicology and Applied Pharmacology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Melamine
- EC Number:
- 203-615-4
- EC Name:
- Melamine
- Cas Number:
- 108-78-1
- Molecular formula:
- C3H6N6
- IUPAC Name:
- 1,3,5-Triazine-2,4,6(1H,3H,5H)-triimine
- Details on test material:
- - IUPAC Name: Melamine
- InChI: 1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)
- Smiles: c1(nc(nc(n1)N)N)N
- Molecular formula :C3H6N6
- Molecular weight :126.122 g/mole
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Frederick Cancer Research Center (Frederick, Md.)
- Age at study initiation: 10-week-old rats
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- not specified
- Doses:
- Range from 2150 to 10,000 mg/kg bw
- No. of animals per sex per dose:
- groups of 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- LD50 values were determined by probit analysis (Finney, 1964)
Results and discussion
- Preliminary study:
- not specified
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 161 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 344 - 4 722
- Remarks on result:
- other: 50% mortality observed
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 828 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 787 - 5 255
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed at 3161 mg/kg bw in male rats and 3828 mg/kg bw in female rats.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose (LD50) was considered to be 3161 mg/kg bw, with 95% confidence limit of 1344-4722 mg/kg bw in male rats and 3828 mg/kg bw, with 95% confidence limit of 2787-5255 mg/kg bw in female rats, when groups of 5 male and 5 female Fischer 344 rats were treated with test chemical via oral gavage route.
- Executive summary:
The acute oral toxicity study was conducted by using test chemical in groups of 5 male and 5 female Fischer 344 rats at the dose concentration range from 2150 to 10,000 mg/kg bw. The given test chemical was dissolved in corn oil and administered via oral gavage route.Five dose levels of test chemical were included in each study. LD50 values were determined by probit analysis (Finney, 1964) and were based on deaths occurring within 14 days after administration. 50% mortality observed at 3161 mg/kg bw in male rats and 3828 mg/kg bw in female rats. Therefore, LD50 was considered to be 3161 mg/kg bw, with 95% confidence limit of 1344-4722 mg/kg bw in male rats and 3828 mg/kg bw, with 95% confidence limit of 2787-5255 mg/kg bw in female rats, when groups of 5 male and 5 female Fischer 344 rats were treated with test chemical via oral gavage route.
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