Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-954-8 | CAS number: 7782-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Investigative published human volunteer study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of fluorine short-term inhalation
- Author:
- Keplinger ML and Suissa LW
- Year:
- 1 968
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 29:10-18
Materials and methods
- Type of study / information:
- Human volunteer study.
- Endpoint addressed:
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Assessment of biochemical and cellular measures of respiratory irritation in human volunteers following a single inhalation exposure to Fluorine gas.
- GLP compliance:
- no
Test material
- Reference substance name:
- Fluorine
- EC Number:
- 231-954-8
- EC Name:
- Fluorine
- Cas Number:
- 7782-41-4
- Molecular formula:
- F2
- IUPAC Name:
- fluorine
- Test material form:
- gas
- Details on test material:
- No further information.
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Five volunteers (19-50 years of age; gender not specified) were exposed to fluorine through a face mask that covered the eyes and nose but not the mouth.
- Exposure assessment:
- measured
- Details on exposure:
- Inhalation: 10-100 ppm for various exposure durations.
Results and discussion
- Results:
- 10 ppm for 15 min: no eye, nose or respiratory irritation
25 ppm for 5 min: eye irritation
50 ppm for 3 min: irritating to eyes, slightly irritating to nose
67 ppm for 1 min: irritating to eyes and nose
100 ppm for 1 min: very irritating to eyes and nose; subjects did not inhale. The skin of the face was very slightly irritated and felt 'sticky'
Any other information on results incl. tables
When exposure to fluorine was repeated at weekly intervals, the subjects did not notice as much irritation as they did on the first exposure. A few repeated intermittent exposures at a concentration of 10 ppm were made. Exposure for three to five minutes every 15 minutes over a two- or three-hour period caused slight irritation to the eyes and skin, but no other subjective effects.
Applicant's summary and conclusion
- Executive summary:
Five volunteers (19–50 years of age; gender not specified) were exposed to fluorine through a face mask that covered the eyes and nose but not the mouth. A concentration of 10 ppm was not irritating to the respiratory tract for at least 15 minutes. Slight nasal irritation was reported following a 3-minute exposure to 50 ppm, and exposure to 100 ppm for 0.5 or 1 minute was very irritating to the nose and eyes. Intermittent inhalation (3–5-minute exposure every 15 minutes for 2–3 hours) of 10 ppm caused slight irritation to the eyes and skin but did not cause respiratory difficulty.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.