Registration Dossier
Registration Dossier
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EC number: 256-852-0 | CAS number: 50925-66-1
Endpoint summary
Administrative data
Description of key information
Extensive testing has been performed on chromium and fluoride salts. Other than where there is corrosivity, chromium II is not considered acutely toxic.
The acute toxic effects and potential for irritation depend very much on the counter ions and pH. Salts with an extreme pH will be strongly irritant and perhaps corrosive to skin, and as such, will cause damage to skin, gastro-intestinal tract and respiratory system. Chromium fluoride as supplied is acidic and may induce local effects if tested on animals; performing new animal tests is not considered appropriate.
Sodium fluoride is soluble in water and has been tested for acute oral toxicity; in one study, all animals died at 2000 mg/kg, but there was no mortality at 200 mg/kg. A second study reported an LD50 of just over 200 mg/kg. The primary sources of these data are unknown, but the same figures appear in the sodium fluoride REACH dossier and can be considered reliable. [Ref 1].
One reliable primary reference suggested an LD50 of 253 mg/kg and is within the range of other tests [ref 2]. As a result of these studies, sodium fluoride is classified as Acute Tox 3. As sodium is itself not hazardous at this sort of concentration, the toxicity is considered due to soluble fluoride ions.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 230 mg/kg bw
- Quality of whole database:
- Determined by toxicity to flouride salts. All data indicates low oral toxicity of chromium III
Acute toxicity: via inhalation route
Endpoint conclusion
- Quality of whole database:
- In view of the physical form of the substance, inhalation is not seen as a significant route of exposure. Animal testing is not justifed.
Acute toxicity: via dermal route
Endpoint conclusion
- Quality of whole database:
- Low toxicity of chromium III. However, some salts are considered potentially corrosive.
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
