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EC number: 226-033-2 | CAS number: 5235-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- The study described in this report was conducted in a facility which operates in accordance with Good Laboratory Practice principles, however no claim of GLP compliance was intended nor is made for this study.
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: 4-(3-(1-napthylamino)propyl)morpholine
Appearance/Physical state: brown/black granular solid
Batch: ZA01212016
Purity: 94.4%
Expiry date: 20 January 2019
Storage conditions: room temperature in the dark - Key result
- Water solubility:
- 0.536 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7.47
- Conclusions:
- The water solubility of the test item has been determined to be 0.536 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
Water Solubility. 0.536 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Preliminary Test Results:
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 0.415 g/L. The solution had a pH of 7.82.
Definitive Test Results:
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 102 mg/L |
5.9446 x 107 |
Standard 203 mg/L |
1.1737 x 108 |
Standard 203 mg/L |
1.0921 x 108 |
Standard 508 mg/L |
2.9041 x 108 |
Standard 761 mg/L |
3.9823 x 108 |
Standard 1.02 x 103mg/L |
4.7910 x 108 |
Sample 1A |
1.4108 x 108 |
Sample 1B |
1.4024 x 108 |
Sample 2A |
1.5790 x 108 |
Sample 2 B |
1.6024 x 108 |
Sample 3A |
1.7239 x 108 |
Sample 3B |
1.7271 x 108 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
0.479 |
7.70 |
2 |
48 |
0.541 |
7.51 |
3 |
72 |
0.587 |
7.20 |
Mean concentration : 0.536 g/L
at 20.0 ± 0.5 ºC
Range : 0.479 to 0.587 g/L
Standard Deviation : 4.83
x 10-2
Mean pH: 7.47
Validation:
An assessment of the relationship between amount of test item and response gave a curve therefore a quadratic model was used for the calibration. A correlation coefficient (r) of 1.000 was obtained and this was deemed acceptable for the test.
Discussion:
On completion of the equilibration period, the samples contained a large excess test item present at the bottom of the test vessels. After centrifugation, the supernatant was taken for analysis. The supernatant was visually observed to be clear, slightly orange in color and free from undissolved test item. A slight Tyndall beam was noted however this was not considered significant.
The test item consisted of multiple components therefore the total area of all sample peaks were used for the calculation. The profile of the samples differed from that of the standards due to the earlier eluting peaks having higher solubility than the later eluting peaks.
A slight increase in concentration with shaking time was noted, however all results fell within ± 15% as specified by the test guidelines.
Description of key information
Water Solubility. 0.536 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Key value for chemical safety assessment
- Water solubility:
- 0.536 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item has been determined to be 0.536 g/L of solution at 20.0 ± 0.5 °C.
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