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Diss Factsheets
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EC number: 608-554-0 | CAS number: 3090-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1967-09-26 to 2016-10-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard
The test substance was administered to mice by i.p. injection. - GLP compliance:
- no
Test material
- Reference substance name:
- Ethanol, 2-(ethenylthio)-
- EC Number:
- 608-554-0
- Cas Number:
- 3090-56-0
- Molecular formula:
- C4H8OS
- IUPAC Name:
- Ethanol, 2-(ethenylthio)-
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- No specific details for test material were provided.
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details were provided.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: water emulsion containing Traganth
- Details on exposure:
- - Application form: emulsion
- Concentration in vehicle: 2, 4, 8 and 20 % (v/v) - Doses:
- 0.2, 0.4, 0.5, 0.64, 0.8 and 1.6 mL/kg
213.38, 426.76, 533.45, 682.82, 853.52 and 1707.04 mg/kg (calculated from mL/kg with a density of 1.0669 g/cm^3) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.57 mL/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 608.13 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1.6 mL/kg: All 10 animals died within 24 h after application.
0.8 mL/kg: 9 animals died within 24 h after application. 1 animal died within 48 h after application.
0.64 mL/kg: 6 animals died within 24 h after application. 2 animals died within 48 h after application. 1 animal died between 48 h and 7 days after application.
No further mortality was observed. - Clinical signs:
- Directly after application animals started to show forced breathing, dragging of hind legs, shaking, staggering walk, spasms, ventral position, partially anesthetic like behavior, closed eyes and dyspnea. Survivors presented with unchanged symptoms for 1 day. Afterwards animals recovered and were without symptoms after 3-5 days.
- Body weight:
- Body weights were not determined.
- Gross pathology:
- In 5 animals that died after treatment weak agglutinations of liver and surrounding organs was detected. In sacrificed animals 11 weak agglutinations and 3 strong adhesions of liver and surrounding organs were detected.
No other observations were made in survivors or animals that died after treatment. - Other findings:
- No other observations were made.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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