Registration Dossier
Registration Dossier
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EC number: 282-162-4 | CAS number: 84100-84-5
Endpoint summary
Administrative data
Description of key information
For 2,3,3-trimethyl-3H-indole-5-carboxylic acid a 48h-EC50 of >100 mg/L was determined for dapnids under exposure conditions.
In a acute fish study (Brachydanio rerio) the mortality was 100 % at concentrations > 100 mg/L after 24 h. However, this effect could also be ascribed to the decrease of the pH-value after 24 h (4.6 at 100 mg/L and 4.2 at 2000 mg/L) due to intrinsic properties of 2,3,3-trimethyl-3H-indole-5-carboxylic acid as Brachydanio rerio should be kept at pH-values between 6.0 and 8.0 according to the test guideline. At a concentration of 70.7 mg/L the pH-value is 6.6 after 24 h and 5.8 after 96 h. No mortality is observed at this concentration. Thus it is most likely that the low pH-value is the reason for mortality at 100 mg/L and not the toxicity of the substance. Therefore no LC50 could be determined and just a LC0 of >=70.7 mg/L is derived.
Additional information
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