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EC number: 220-076-0 | CAS number: 2623-23-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available on the environmental fate ofthe target substance (L-menthyl acetate, CAS 2623-23-6). In order to fulfil the standard information requirements read-across from structurally related substances was conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, “information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity. Please refer to IUCLID section 13 for a detailed justification of the analogue approach.
The source substance menthyl acetate (CAS 89-48-5) was used for read-across purposes. This substance is a racemic mixture of L-menthyl acetate and D-menthyl acetate thus containing the target substance (L-menthyl acetate, CAS 2623-23-6). The presence of D-menthyl acetate in the mixture is not considered to have a remarkable impact on the assessment of the environmental fate of the target substance. For the structurally similar stereoisomers D- and L-menthol it was shown that their different isomeric structure has no impact on the overall environmental fate/behavior as discussed and justified in the OECD SIDS report (OECD, 2003).
Based on the result from one experimental study performed with the
source substance menthyl acetate (CAS 89-48-5) according to EU Method
C.4-E it can be concluded that the target substance (L-menthyl acetate)
is not readily biodegradable according to the OECD criteria (48%
degradation after 28 d based on O2 consumption, ongoing biodegradation).
Taking into account additional reliable (Q)SAR calculations the
substance can be considered as inherently biodegradable and not likely
to be persistent in the environment.
As the source substance hydrolyses quite fast under environmental conditions (pH7) with a half-life of only 6 days, the target substance can be regarded as rapidly degradable under environmental conditions. With a half-life time of < 16 days the criteria for rapid degradation according to the CLP/GHS criteria are as well fulfilled as the degradation products L-Menthol (CAS 2216 -51 -5) and acetic acid (CAS 64-19-7) are not classified as hazardous to the aquatic environment. Furthermore, referring to ECHA PBT guidance document a "substance fulfils the P(vP) criterion if T1/2 > 40 (60) days". As it further can be shown that the two expected hydrolysis transformation products L-Menthol and acetic acid are not PBT/vPvB, according to ECHA PBT guidance document no further testing of degradation is required for the PBT/vPvB assessment. A persistence of L-menthyl acetate in the environment is therefore not expected.
Considering the water solubility of 21.0 - 25.4 mg/L and the low to moderate potential for adsorption to organic soil and sediment particles (log Koc: 2.69 - 3.29L/kg, KOCWIN v2.00), the main compartment for environmental distribution is expected to be the surface water. However, the substance might evaporate into the atmospheric compartment based on the vapour pressure of 45 Pa at 20 °C and a Henry’s Law Constant of 84 - 100 Pa m³/mole (HenryWin v3.20).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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