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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Glass dust: A study of its biologic effects
- Author:
- Gross P, M.L.Westrick
- Year:
- 1 960
- Bibliographic source:
- AMA Arch Ind Health 21:10-23
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two experiments were performed, each using six eyes of albino rabbits. In the first, the lids were held open only long enough to dust the ocular conjunctiva thoroughly with the finely miIled glass flakes (the largest particles around 400 microm but the vast majority less than 50 microm). In the second experiment, the lids were held open about one minute after the dusting. The eyes were examined 24 hours later with the aid of fluorescein.
- GLP compliance:
- no
Test material
- Reference substance name:
- Glass
- EC Number:
- 920-837-3
- IUPAC Name:
- Glass
- Details on test material:
- The glass dust used in this investigation prepared from flakes of glass (Fiberglas Flake) which were approximately 5 microm thick. The glass contained, in addition to SiO2, the oxides of Al, Ca, Mg, and B as major constitllents. AIso present, but in amounts less than 1'% and usually more than trace, were the followingelemellts: Na, K, Ti, Fe, and Zr.
A coarse dust was prepared by milling the flakes so that the resulting particles passed a 32S mesh sieve.
The largest particles were around 400 microm but the vast majority less than 50 microm
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: "albino"
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Not specified. the lids were held open only long enough to dust the ocular conjunctiva thoroughly with the finely miIled glass ftakes (the largest
particles around 400microm but the vast majority less than 50microm) - Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 24h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Two experiments were performed, each using six eyes of albino rabbit!s. In the first, the lids were held open only long enough to dust the ocular conjunctiva thoroughly with the finely miIled glass flakes (the largest particles around 400 microm but the vast majority less than 50 microm). In the second experiment, the lids were held open about one minute after the dusting. The eyes were examined 24 hours later with the aid of fluorescein.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: no corneal defects were observed
- Basis:
- animal #6
- Time point:
- other: 24 h
- Score:
- 0
- Irritant / corrosive response data:
- No corneal defects were observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The glass particles did not reveal any corneal effects.
- Executive summary:
Glass particles (mostly less than 50 microm and upto 400 microm) did not show any corneal effetcts when applied to rabbit eyes (Gross et al. 1960). The particles were effectively cleared from conjunctiva by blinking.
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