Registration Dossier
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EC number: 260-925-2 | CAS number: 57741-47-6
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium 6 -amino-5 -[[4 -chloro-2 -(trifluoromethyl)phenyl]azo]-4 -hydroxynaphthalene-2 -sulphonate was estimated to be 11.3 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate is non-bioaccumulative in nature.
Additional information
Bioaccumulation: aquatic / sediment
Predicted data for the target compound sodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate (CAS No. 57741-47-6) and supporting study for its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium 6 -amino-5 -[[4 -chloro-2 -(trifluoromethyl)phenyl]azo]-4 -hydroxynaphthalene-2 -sulphonate was estimated to be 11.3 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and Envichem, 2018) for the read across chemical 8-amino-1-naphthol-3,6-disulfonic (CAS no. 5460-09-3),bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of 8-amino-1-naphthol-3,6-disulfonic. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 2mg/l and 0.2 mg/l, respectively. Range finding study involve the TLm (48 hr) 880 mg/l (w/v) onRice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance 8-amino-1-naphthol-3,6-disulfonic on Cyprinus carpio was determined to be ≤ 0.3 L/Kg at a conc. of 2 mg/l and ≤ 2.9 L/Kg at a conc. of 0.2 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 8-amino-1-naphthol-3,6-disulfonic is not expected to bioaccumulate in the food chain.
On the basis of above overall results for target chemicalsodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate(from Comptox Chemistry Dashboard,2018) and for its read across substance from authoritative database (J-CHECK, 2017 and EnviChem, 2014), it can be concluded that the BCF value of test substance sodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate was estimated to be 11.3, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical sodium 6-amino-5-[[4-chloro-2-(trifluoromethyl)phenyl]azo]-4-hydroxynaphthalene-2-sulphonate is not expected to bioaccumulate in the food chain.
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