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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 615-064-0 | CAS number: 700874-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 80.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEC
- Value:
- 12 000 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 6 030 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor is modified according to the following :
Modified inhal. human NOAEC = rat inhal NOAEC * exp. cond. rat/expo. cond. human
Modified inhal. human NOAEC = 12000 mg/m3 * 6h/8h * 1 * 6.7 m3 (8h)/10 m3 (8h) = 6030 mg/m3
with modifications applied:
Rat experimental Worker exposure correction Point of departure Inhalation NOAEC: 12000 mg/m3 exposure condition (hours) 6h/day 8h/day 0.75 exposure condition (days/week) 7 days/week (Default is 5d/week) 5 days/week Default: 1 sRV (human) 6.7 m3/8h shift 6.7 wRV (human) 10 m3 /8h shift (light work) 10 0.5025 - AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 6
- Justification:
- sub-acute study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 40.27 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor:
- NOAEC
- Value:
- 3 020 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Default value. A dose-dependent response was observed.
The effects on the nasal epithelium were observed only at the highest dose. - AF for differences in duration of exposure:
- 6
- Justification:
- Default value. Local effects were observed in a repeated-dose toxicity study (28-day/OECD422), but not in the acute inhalation study following a single exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The starting point is an inhalation study
- AF for other interspecies differences:
- 1
- Justification:
- Findings were alterations in the nasal cavity. A greater sensitivity in rats is usually observed compared to humans because of the physiological differences in the rat nasal cavity (in particular due to the larger epithelium surface in contact with incoming airflow).
- AF for intraspecies differences:
- 5
- Justification:
- Default guidance value for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default value. Effects on the nasal cavity were documented in a reliable 28-day study in rats.
- AF for remaining uncertainties:
- 2.5
- Justification:
- No local effects were identified in the acute inhalation toxicity study.
Local effects on nasal ephitelium are probably related to the exposure duration as they were only observed in the repeated dose study by inhalation.
In the absence of information related to the mechanism leading to the nasal effects, an assessment factor for remaining uncertainty is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEC
- Value:
- 12 000 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 3 420 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor is modified according to the following exposure conditions:
Modified inhal. human NOAEC = rat inhal NOAEC * exp. cond. rat/expo. cond. human
Modified inhal. human NOAEC = 12000 mg/m3 * 6h/8h = 9000 mg/m3
The dose descriptor is then corrected for absorption differences, if any.
Modified dermal human NOAEL = rat inhal NOAEC * sRVrat * ABS(inhal,rat)/ABS(dermal, rat) * ABS (dermal, rat)/ABS (dermal, human)
Modified inhal. human NOAEC = 9000 mg/m3 * 0.38 m3/kg/d * 1 = 3420 mg/kg/day
with Default inhalation absorption = 1 and Default dermal absorption = 1
and the following modifications
Rat (experimental) gen. pop. exposure correction Point of departure Inhalation NOAEC: 12000 mg/m3 exposure condition (hours) 6h/day 8h/day 0.75 exposure condition (days/week) 7 days/week (Default is 5d/week) 7 days/week Default applied 1 Absorption (inahalation) 1 Absorption (dermal) 1 1 sRV 0.38 m3/kg/d (6h --> 8h) - AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEC
- Value:
- 12 000 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 3 000 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor is modified according to the following :
Modified inhal. human NOAEC = rat inhal NOAEC * exp. cond. rat/expo. cond. human
Modified inhal. human NOAEC = 12000 mg/m3 * 6h/24h = 3000 mg/m3
with the following modifications
Rat experimental gen. pop. exposure correction Point of departure Inhalation NOAEC: 12000 mg/m3 exposure condition (hours) 6h/day 24h/day 0.25 exposure condition (days/week) 7 days/week (Default is 5d/week) 7 days/week 1 0.25 - AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20.13 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor:
- NOAEC
- Value:
- 3 020 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Default value. A concentration-dependent response was observed.
The effects on the nasal epithelium were observed only at the highest dose. - AF for differences in duration of exposure:
- 6
- Justification:
- Default value. Local effects were observed in a repeated-dose toxicity study (28-day/OECD422)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The starting point is an inhalation study
- AF for other interspecies differences:
- 1
- Justification:
- Findings were alterations in the nasal cavity. A greater sensitivity in rats is usually observed compared to humans because of the physiological differences in the rat nasal cavity (in particular due to the l
arger epithelium surface in contact with incoming airflow). - AF for intraspecies differences:
- 10
- Justification:
- Default guidance value for general population.
- AF for the quality of the whole database:
- 1
- Justification:
- Default value. Effects on the nasal cavity were documented in a reliable 28-day study in rats.
- AF for remaining uncertainties:
- 2.5
- Justification:
- No local effects were identified in the acute inhalation toxicity study.
Local effects on nasal ephitelium are probably related to the exposure duration as they were only observed in the repeated dose study by inhalation.
In the absence of information related to the mechanism leading to the nasal effects, an assessment factor for remaining uncertainty is applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.75 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEC
- Value:
- 12 000 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 3 450 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor is modified according to the following exposure conditions:
Modified inhal. human NOAEC = rat inhal NOAEC * exp. cond. rat/expo. cond. human
Modified inhal. human NOAEC = 12000 mg/m3 * 6h/24h = 3000 mg/m3
The dose descriptor is then corrected for absorption differences, if any.
Modified dermal human NOAEL = rat inhal NOAEC * sRVrat * ABS(inhal,rat)/ABS(dermal, rat) * ABS (dermal, rat)/ABS (dermal, human)
Modified inhal. human NOAEC = 3000 mg/m3 * 1.15 m3/kg/d * 1 = 3450 mg/kg/day
with Default inhalation absorption = 1 and Default dermal absorption = 1
and the following modifications
Rat (experimental) gen. pop. exposure correction Point of departure Inhalation NOAEC: 12000 mg/m3 exposure condition (hours) 6h/day 24h/day 0.25 exposure condition (days/week) 7 days/week (Default is 5d/week) 7 days/week 1 Absorption (inahalation) 1 Absorption (dermal) 1 1 sRV 1.15 m3/kg/d (6h --> 24h) - AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 6
- Justification:
- 28 day study to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- inhalation to dermal
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator) for general population
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.75 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEC
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 3 450 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The dose descriptor is modified according to the following exposure conditions:
Modified inhal. human NOAEC = rat inhal NOAEC * exp. cond. rat/expo. cond. human
Modified inhal. human NOAEC = 12000 mg/m3 * 6h/24h = 3000 mg/m3
The dose descriptor is then corrected for absorption differences, if any.
Modified oral human NOAEL = rat inhal NOAEC * sRVrat * ABS(inhal,rat)/ABS(oral, rat) * ABS (oral, rat)/ABS (oral, human)
Modified oral human NOAEL = 3000 mg/m3 * 1.15 m3/kg/d * 1 = 3450 mg/kg/day
with Default inhalation absorption = 1 and Default oral absorption = 1
and the following modifications
Rat (experimental) gen. pop. exposure correction Point of departure Inhalation NOAEC: 12000 mg/m3 exposure condition (hours) 6h/day 24h/day 0.25 exposure condition (days/week) 7 days/week (Default is 5d/week) 7 days/week 1 Absorption (inhalation) 1 Absorption (oral) 1 1 sRV 1.15 m3/kg/d (6h --> 24h) - AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 6
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default for general population (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
No direct exposure of the general population is anticipated as MOVE 3 is only used at industrial facilities.
The potential of exposure of general population is limited to indirect exposure by the environment, which is however limited because of the design of the industrial processes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.