Registration Dossier
Registration Dossier
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EC number: 234-911-1 | CAS number: 12039-90-6
Endpoint summary
Administrative data
Description of key information
In a bio-elution test it was shown that only 17.45 µg/L zirconium was released after 72 hours in artificial perspiration fluid (see IUCLID section 7.1.1). Moreover, the test substance was highly insoluble (below detection limit) in a T/D test conducted in accordance with OECD 29 (see IUCLID section 4.8). Thus, the bioavailability of zirconium, as the toxicological relevant part of the target substance, after administration to the skin, can be expected to be very low. No information was found in the public domain, which would indicate any skin sensitising properties of zirconium. Based on the results and in line with the 3R principles, the study is scientifically unjustified.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In a bio-elution test it was shown that only 17.45 µg/L zirconium was released after 72 hours in artificial perspiration fluid (see IUCLID section 7.1.1). Moreover, the test substance was highly insoluble (below detection limit) in a T/D test conducted in accordance with OECD 29 (see IUCLID section 4.8). Thus, the bioavailability of zirconium, as the toxicological relevant part of the target substance, after administration to the skin, can be expected to be very low. No information was found in the public domain, which would indicate any skin sensitising properties of zirconium. Based on the results and in line with the 3R principles, the study is scientifically unjustified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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