Registration Dossier
Registration Dossier
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EC number: 271-626-1 | CAS number: 68602-85-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 000 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 000 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
The substance is not acutely toxic via the oral route (LD50 > 2000 mg/kg) and oral administration of test item to rats by gavage, at dose levels of 350, 700 and 1000 mg/kg bw/day, was well tolerated in 28-day repeated dose oral toxicity (OECD 407) and reproductive/developmental toxicity screening (OECD 421) studies (NOAEL 1000 mg/kg bw/day). Moreover, no evidence of skin corrosion/irritation or skin sensitisation was found during performance of relevant investigations. In the absence of systemic or local effects by the oral or dermal route it is not possible or appropriate to derive DNEL values.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 000 mg/m³
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 000 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 000 mg/kg bw/day
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
The substance is not acutely toxic via the oral route (LD50 > 2000 mg/kg) and oral administration of test item to rats by gavage, at dose levels of 350, 700 and 1000 mg/kg bw/day, was well tolerated in 28-day repeated dose oral toxicity (OECD 407) and reproductive/developmental toxicity screening (OECD 421) studies (NOAEL 1000 mg/kg bw/day). Moreover, no evidence of skin corrosion/irritation or skin sensitisation was found during performance of relevant investigations. In the absence of systemic or local effects by the oral or dermal route it is not possible or appropriate to derive DNEL values.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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