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EC number: 208-914-3 | CAS number: 546-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The Comparative Toxicity of certain Lithium compounds in acute experiments on animals
- Author:
- Neretin, V.
- Year:
- 1 958
- Bibliographic source:
- Farmakol Toksikol. 1958 Jul-Aug;21(4):93-5.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Parameters analysed / observed: The minimum lethal dose was investigated. The toxicity of the test substance was determined according to the survival of the animals and their general conditions. The animals were observed for 30 days after the administration of the solution.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lithium acetate
- EC Number:
- 208-914-3
- EC Name:
- Lithium acetate
- Cas Number:
- 546-89-4
- Molecular formula:
- LiCH3CO2 (not C2H4O2.Li)
- IUPAC Name:
- lithium acetate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 21 - 23 g
- Acclimation period: 10 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1 mL
- No. of animals per sex per dose:
- 20
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 1 500 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Animals that died revealed morphological changes of the lungs, brain and liver that were characterised as sharply expressed polyemia. Selective degeneration mainly affected liver, kidney and the nervous system. Morphological changes increased with the dosage of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- According to Neretin et al. an LDLo of 1500 mg/kg bw was determined for mice.
- Executive summary:
Lithium acetate was tested on 20 white mice per dose group in an acute toxicity study (Neretin, 1958). The LDLo- and LD100-levels in this study were 1500 mg/kg bw and 4000 mg/kg bw, respectively.
Animals that died revealed morphological changes of the lungs, brain and liver that were characterised as sharply expressed polyemia. Selective degeneration mainly affected liver, kidney and the nervous system. Morphological changes increased with the dosage of the test substance.
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