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Diss Factsheets
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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- 2-Methoxyethanol Metabolism in Pregnant CD-1 Mice and Embryos
- Author:
- Mebus CA, Clarke DO, Stedman DB, Welsch F
- Year:
- 1 992
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY, 112: 87-94.
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- Methoxyacetic acid was obtained from Eastman Kodak Co. (Lot No. B10E). No purity is indicated. Isotope [1-14C]Methoxyacetic acid was obtained from Wizard Laboratories and was >98% radiochemically pure. [2-14C]Methoxyacetic acid and [methoxy-14C]Methoxyacetic acid were generated in vivo.
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Metabolism of Methoxyacetic acid in vivo:
Dosing solutions for gavage were prepared freshly by neutralizing 100 µL of Methoxyacetic acid with 900 µL of 10% sodiumcarbonate solution and diluting further with 1 ml of acidified water with a pH value of ~2.0. The pH value was checked with a pH indicator paper to assure that it was in the range of 7.0 to 7.4. Single oral dose (3.3 mmol/kg) was administered at 5.04 µL/g bw in combination with a tracer dose of 2 µCi of [1-14C]Methoxyacetic acid. Control animals received an equivalent volume of the vehicle.
- No. of animals per sex per dose / concentration:
- Three pregnant females.
- Control animals:
- yes, concurrent vehicle
- Details on dosing and sampling:
- Metabolism of Methoxyacetic acid in vivo:
Immediately after dosing, animals were placed into an individual glass metabolic cage. Exhaled air were passed through CO2 traps and urine was collected from each dam over 12-hr intervals up to 48 hr. Aliquots of the trapping solution and of the urine samples were analyzed to detect radio-labelled parent substance and metabolites.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
Any other information on results incl. tables
Present data obtained with [1-14C]Methoxyacetic acid revealed that metabolism beyond 2-Methoxyacetic acid occurs. Dams exhaled ~6% of the radioactivity administered as a single teratogenic oral dose (3.3 mmol/kg on gestation day 11) as14CO2. Examined urine contained ~70% of the dose within 24 hr after administration and ~11% in the next 24 hrs. Three labeled products were resolved using HPLC: an unidentified Peak A (12-18% of dose), Methoxyacetic acid (~50%), and the glycine conjugate of Methoxyacetic acid (~25%). Short-term (4 hr) whole embryo culture on gestation day 11 with 3 mM 2-Methoxyacetic acid and a tracer dose of [1-14C]Methoxyacetic acid, [2 -14C]Methoxyacetic acid, or [methoxy-14C]Methoxyacetic acid showed that14CO2 evolved from the former two substrates, while there was none detectable from the latter. The data indicate that dams metabolized [methoxy-14C]Methoxyacetic acid to14CO2, while embryos apparently did not.
Applicant's summary and conclusion
- Executive summary:
- Conclusions: Complete absorption following a single oral dose; eliminated as CO2 (11 % of dose) in expired air and rapidly via urine (> 81 %, ~ 70 % within 24 h) as parent compound (~50 %), the glycine conjugate (~25 %) and unidentified metabolite (12 - 18 %).
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