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EC number: 601-601-6 | CAS number: 119345-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP, but the report contains sufficient data for interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin irritation test included topical application of 0.1 ml of neat Dowfax 2A1 to the ear, and 0.5 ml to intact and abraded skin on the abdomen of a male New Zealand White (NZW) rabbit. The animal was bandaged for 24 hours after application of the test material to provide occlusion and prevent grooming of the application site. Twenty four hours after application the bandage was removed and the application sites were
graded. Five consecutive daily doses of Dowfax 2A1 were applied to the intact abdominal skin, and the apex of the left pinna, and three consecutive daily applications to the abraded abdominal site. Observations were recorded up to 72 hours after the final dose. - GLP compliance:
- no
Test material
- Reference substance name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- EC Number:
- 601-601-6
- Cas Number:
- 119345-04-9
- Molecular formula:
- C24H32O7S2Na2
- IUPAC Name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- Details on test material:
- Test material: Dowfax 2A1
Source: Specialty Chemicals, The Dow Chemical Company
Properties: Amber liquid
pH= 7.0
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Male New Zealand White rabbit.
Test system
- Type of coverage:
- other: ear- open; intact and abraded abdomen- occluded
- Preparation of test site:
- other: shaved intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml- ear
0.5 ml- intact and abraded abdomen - Duration of treatment / exposure:
- Five consecutive daily doses of Dowfax 2A1 were applied to the intact abdominal skin, and the apex of the left pinna, and three consecutive daily
applications to the abraded abdominal site. - Observation period:
- Twenty four hours after application the bandage was removed and the application sites were graded. Observations were recorded out to 72 hours after the last dose.
- Number of animals:
- 1
- Details on study design:
- The skin irritation test included topical application of 0.1 ml of neat Dowfax 2A1 to the ear, and 0.5 ml to intact and abraded skin on the abdomen of a male New Zealand White (NZW) rabbit. The abdomen of the rabbit was shaved with a straight razor at least three days prior to test initiation. The animal was bandaged for 24 hours after application of the test material to provide occlusion and prevent grooming of the application site. Twenty four hours after application the bandage was removed and the application sites were graded. Five consecutive daily doses of Dowfax 2A1 were applied to the intact abdominal skin, and the apex of the left pinna, and three consecutive daily applications to the abraded abdominal site. The study was terminated 72 hours after the final dose.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1d, 2d, 3d, 4d, 5d
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- ear/all timepoints/ Non-Draize test
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1d, 2d, 3d, 4d, 5d
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- ear/all timepoints/Non-Draize test
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1d, 2d, 3d, 4d
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Intact abdomen/ Non-Draize test
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: day 5
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Intact abdomen/Non-Draize test
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1d, 2d, 3d, 4d, 5d
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Remarks:
- abraded abdomen/ all timepoints/Non-Draize test
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: day 1
- Score:
- 1
- Max. score:
- 6
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- abraded abdomen/Non-Draize test
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 2d, 3d, 4d, 5d
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- abraded abdomen/Non-Draize test
- Irritant / corrosive response data:
- No irritation was observed on the ear. Very slight erythema was observed at the intact site after the last application. Very slight erythema was observed at the abraded site on test day two through test day five. The study was terminated 72 hours after the final dose.
- Other effects:
- The animal survived the test period. No clinical signs indicative of systemic toxicity were observed.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- No irritation was observed on the ear. Very slight erythema was observed at the intact site after the last application. Very slight erythema was observed at the abraded site on test day two through test day five. The study was terminated 72 hours after the final dose.
- Executive summary:
A sample of Dowfax 2A1 was submitted by Specialty Chemicals, The Dow Chemical Company, Midland, MI for evaluation of acute oral and dermal toxicity and skin and eye irritation. This compound is a potential surfactant in cleaning solutions.
The skin irritation test included topical application of 0.1 ml of neat Dowfax 2A1 to the ear, and 0.5 ml to intact and abraded skin on the abdomen of a male New Zealand White (NZW) rabbit. Five consecutive daily doses of Dowfax 2A1 were applied to the intact abdominal skin, and the apex of the left pinna, and three consecutive daily applications to the abraded abdominal site. No irritation was observed on the ear. Very slight erythema was observed at the intact site after the last application. Very slight erythema was observed at the abraded site on test day two through test day five. The study was terminated 72 hours after the final dose. Based on the outcomes on the intact ear and abdomen rabbit skin, it was concluded that Dowfax 2A1 has only minimal skin irritation potential.
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