Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 264-165-2 | CAS number: 63449-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted in March 1977.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Reliability 2 is assigned because although the study was conducted similar to the current OECD TG 401, the study is non-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(isopropyl)cyclohexyl propionate
- EC Number:
- 264-165-2
- EC Name:
- 4-(isopropyl)cyclohexyl propionate
- Cas Number:
- 63449-95-6
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 4-(isopropyl)cyclohexyl propionate
- Test material form:
- other: liquid
- Details on test material:
- - Storage condition of test material: Store in cool dark place at room temperature
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Test substance was administered undiluted in a single oral dose to nonfasted rats.
- Doses:
- Five doses were used in the study: 3980, 5010, 6310, 7940 and 10000 mg/kg bw.
- No. of animals per sex per dose:
- 5 rats per dose
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days.
Animals of two sexes were used instead of one sex.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 950 - < 8 780
- Mortality:
- The following numbers of animals died in the study at the doses:
- 3980 mg/kg bw: 1
- 5010 mg/kg bw: 2
- 6310 mg/kg bw: 2
- 7940 mg/kg bw: 3
- 10000 mg/kg bw: 5. - Clinical signs:
- Signs of intoxication included: reduced appetite and activity (one to five days in survivors), increasing weakness, tremors, convulsions, collapse and death.
- Gross pathology:
- Gross autopsy demonstrated: hemorrhagic areas of the lungs, liver hyperemia and acute gastrointestinal inflammation.
- Other findings:
- In survisors (at 14 days) viscera appeared normal.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- According to EU CLP 1272/2008 and its amendments.
- Conclusions:
- The acute oral toxicity test showed an LD50 of 6600 mg/kg bw. Based on the results of this study, test substance is not acute orally toxic.
- Executive summary:
Acute oral toxicity was performed similar to the guideline OECD TG 401. Five rats (males and females) per dose were administered the substance at doses: 3980, 5010, 6310, 7940 and 10000 mg/kg bw. The following numbers of rats died during the study: 1 at 3980 mg/kg bw, 2 at 5010 mg/kg bw, 2 at 6310 mg/kg bw, 3 at 7940 mg/kg bw and 5 at 10000 mg/kg bw. The clinical signs observed during the study included: reduced appetite and activity (one to five days in survivors), increasing weakness, tremors, convulsions, collapse and death. Gross autopsy demonstrated: hemorrhagic areas of the lungs, liver hyperemia and acute gastrointestinal inflammation. The acute oral LD50 for the substance in male and female rats was determined to be 6600 mg/kg bw, therefore the substance is not toxic by the oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.