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EC number: 240-915-4 | CAS number: 16883-16-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 was estimated to be 2987 mg/kg bw when male and female Wistar rats were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by oral gavage route.
Acute Dermal toxicity:
LD50 was estimated to be 2388 mg/kg bw, when New Zealand White male and female rabbits were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by dermal application semiocclusively.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - IUPAC Name: 5-methyl-3-phenylisoxazole-4-carbonyl chloride
- Mol. formula: C11H8ClNO2
- Molecular Weight: 221.642 g/mol
- Smiles: c1(ccccc1)c1c(C(=O)Cl)c(on1)C
- InChI: 1S/C11H8ClNO2/c1-7-9(11(12)14)10(13-15-7)8-5-3-2-4-6-8/h2-6H,1H3 - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2987 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 987 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 2987 mg/kg bw when male and female Wistar rats were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by oral gavage route.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883 -16 -2). The LD50 was estimated to be 2987 mg/kg bw when male and female Wistar rats were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by oral gavage route.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 7 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and "g" )
and "h" )
and ("i"
and "j" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Oxazole/ Izoxazole by Organic Functional groups
ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Overlapping groups OR Oxazole/ Izoxazole by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] OR
Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Aromatic Carbon
[C] OR Aromatic Nitrogen, five-member ring OR Aromatic Oxygen OR
Carbonyl, olefinic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl]
OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or
=C<] OR Oxygen, nitrogen attach [-O-] by Organic functional groups (US
EPA) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic compound OR Carbonic
acid derivative OR Halogen derivative by Organic functional groups,
Norbert Haider (checkmol) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as SN2 AND SN2 >> Direct acylation
involving a leaving group AND SN2 >> Direct acylation involving a
leaving group >> Acyl Halides by DNA binding by OASIS v.1.3
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Quinones OR AN2 >> Nucleophilic addition to alpha,
beta-unsaturated carbonyl compounds OR AN2 >> Nucleophilic addition to
alpha, beta-unsaturated carbonyl compounds >> alpha, beta-Unsaturated
Aldehydes OR AN2 >> Schiff base formation OR AN2 >> Schiff base
formation >> alpha, beta-Unsaturated Aldehydes OR AN2 >> Schiff base
formation >> Polarized Haloalkene Derivatives OR AN2 >> Thioacylation
via nucleophilic addition after cysteine-mediated thioketene formation
OR AN2 >> Thioacylation via nucleophilic addition after
cysteine-mediated thioketene formation >> Haloalkenes with
Electron-Withdrawing Groups OR AN2 >> Thioacylation via nucleophilic
addition after cysteine-mediated thioketene formation >> Polarized
Haloalkene Derivatives OR Michael addition OR Michael addition >>
Quinone type compounds OR Michael addition >> Quinone type compounds >>
Quinone methides OR No alert found OR Non-covalent interaction OR
Non-covalent interaction >> DNA intercalation OR Non-covalent
interaction >> DNA intercalation >> Quinones OR Radical OR Radical >>
Radical mechanism via ROS formation (indirect) OR Radical >> Radical
mechanism via ROS formation (indirect) >> Quinones OR Radical >> ROS
formation after GSH depletion OR Radical >> ROS formation after GSH
depletion >> Quinone methides OR SN1 OR SN1 >> Alkylation after
metabolically formed carbenium ion species OR SN1 >> Alkylation after
metabolically formed carbenium ion species >> Polycyclic Aromatic
Hydrocarbon Derivatives OR SN2 >> Alkylation, direct acting epoxides and
related OR SN2 >> Alkylation, direct acting epoxides and related >>
Epoxides and Aziridines OR SN2 >> Alkylation, direct acting epoxides and
related after P450-mediated metabolic activation OR SN2 >> Alkylation,
direct acting epoxides and related after P450-mediated metabolic
activation >> Haloalkenes with Electron-Withdrawing Groups OR SN2 >>
Alkylation, direct acting epoxides and related after P450-mediated
metabolic activation >> Polycyclic Aromatic Hydrocarbon Derivatives OR
SN2 >> SN2 at sp3 and activated sp2 carbon atom OR SN2 >> SN2 at sp3 and
activated sp2 carbon atom >> Polarized Haloalkene Derivatives by DNA
binding by OASIS v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Class 3 (unspecific reactivity)
by Acute aquatic toxicity classification by Verhaar (Modified) ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole by Organic Functional
groups ONLY
Domain
logical expression index: "i"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.0156
Domain
logical expression index: "j"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.44
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 987 mg/kg bw
- Quality of whole database:
- Data is Klimicsh 2 and QSAR toolbox 3.3
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - IUPAC Name: 5-methyl-3-phenylisoxazole-4-carbonyl chloride
- Mol. formula: C11H8ClNO2
- Molecular Weight: 221.642 g/mol
- Smiles: c1(ccccc1)c1c(C(=O)Cl)c(on1)C
- InChI: 1S/C11H8ClNO2/c1-7-9(11(12)14)10(13-15-7)8-5-3-2-4-6-8/h2-6H,1H3 - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 2388 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 388
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 2388 mg/kg bw when New Zealand White male and female rabbits were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by dermal application semiocclusively.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883 -16 -2). The LD50 was estimated to be 2388 mg/kg bw when New Zealand White male and female rabbits were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by dermal application semiocclusively.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and "i" )
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and "n" )
and "o" )
and ("p"
and "q" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Oxazole/ Izoxazole by Organic Functional groups
ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Overlapping groups OR Oxazole/ Izoxazole by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] OR
Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Aromatic Carbon
[C] OR Aromatic Nitrogen, five-member ring OR Aromatic Oxygen OR
Carbonyl, olefinic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl]
OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or
=C<] OR Oxygen, nitrogen attach [-O-] by Organic functional groups (US
EPA) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic compound OR Carbonic
acid derivative OR Halogen derivative by Organic functional groups,
Norbert Haider (checkmol) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Lysine peptide depletion
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as High reactive OR High reactive
>> Acrylic acid esters OR High reactive >> Activated 1,3,5-triazine
derivatives OR Low reactive OR Low reactive >> Epoxides OR Low reactive
>> Short-chain alpha-alkyl cinnamaldehyde derivatives OR Moderate
reactive OR Moderate reactive >> Cinnamaldehyde type compounds by DPRA
Lysine peptide depletion
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules (GSH) by Protein binding potency
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Highly reactive (GSH) OR Highly
reactive (GSH) >> Furamates (MA) OR Moderately reactive (GSH) OR
Moderately reactive (GSH) >> 2-Vinyl carboxamides (MA) OR Moderately
reactive (GSH) >> 2-Vinylpyridine (MA) OR Moderately reactive (GSH) >>
Alkyl 2-alkenoates (MA) OR Moderately reactive (GSH) >> Substituted
1-Alken-3-ones (MA) OR Moderately reactive (GSH) >> Substituted
2-Alken-1-als (MA) OR Slightly reactive (GSH) OR Slightly reactive (GSH)
>> 2-Alkenyl carbonitriles (MA) OR Slightly reactive (GSH) >>
Methacrylates (MA) by Protein binding potency
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Metalloids OR
Rare Earth OR Transition Metals by Groups of elements
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND
Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Group 15 - Phosphorus P by
Chemical elements
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Overlapping groups AND Oxazole/ Izoxazole
by Organic Functional groups (nested) ONLY
Domain
logical expression index: "o"
Similarity
boundary:Target:
CC1=C(C(=O)Cl)C(c2ccccc2)=NO1
Threshold=10%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "p"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.474
Domain
logical expression index: "q"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.44
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 388 mg/kg bw
- Quality of whole database:
- Data is Klimicsh 2 and QSAR toolbox 3.3
Additional information
Acute oral toxicity:
In different studies, 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS no: 16883-16-2) has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rats for 5-methyl-3-phenylisoxazole-4-carbonyl chloride along with the study available on structurally similar read across substance Benzoyl chloride (98-88-4) and Methyl benzoylformate (15206-55-0). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883 -16 -2). The LD50 was estimated to be 2987 mg/kg bw when male and female Wistar rats were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by oral gavage route.
The above study supported by U. S. Environmental Protection Agency (2012), for the structurally similar read across substance Benzoyl chloride (98-88-4). Acute oral toxicity study was conducted in 60 (10/dose) male Wistar rats using undiluted Benzoyl chloride. Doses were given in concentration 1210, 1820, 2420, 3030, 3750 or 6040 mg/kg via oral gavage route and observed for 14 days. Mortality was observed at 1820(2), 2420(5), 3030(6), 3750(9) and 6040(10) mg/kg. 50% mortality was observed at dose 2528 mg/kg bw with the Signs of intoxication, sedation, extention spasm, reduced general condition of animals were observed. Hence, LD50 was considered to be 2528 mg/kg bw, when male Wistar rats were treated with Benzoyl chloride (98-88-4) orally.
This is further supported by EUROPEAN COMMISSION – European Chemicals Bureau, IUCLID DATASET (2000), for the structurally similar read across substance Methyl benzoylformate (15206-55-0). Acute oral toxicity study was done in 15 rats using test material Methyl benzoylformate orally. No Mortality was observed at dose 5000 mg/kg bw. Hence, LD50 value was considered to be >5000mg/kg body weight when rats were treated with Methyl benzoylformate (CAS no. 15206-55-0) orally.
Thus, based on the above studies on 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS no: 16883-16-2) and it’s read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 5-methyl-3-phenylisoxazole-4-carbonyl chloride can be classified as category V of acute oral toxicity.
Acute Dermal toxicity:
In different studies, 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS no: 16883-16-2) has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rabbits for 5-methyl-3-phenylisoxazole-4-carbonyl chloride along with the study available on structurally similar read across substance 2-ethylhexanoyl chloride (760-67-8) and Benzoyl Chloride (98-88-4). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883 -16 -2). The LD50 was estimated to be 2388 mg/kg bw when New Zealand White male and female rabbits were treated with 5-methyl-3-phenylisoxazole-4-carbonyl chloride by dermal application semiocclusively.
This is further supported by EUROPEAN COMMISSION – European Chemicals Bureau (IUCLID Dataset, 2000), for the structurally similar read across substance 2-ethylhexanoyl chloride (760-67-8). The acute dermal toxicity was tested in rabbits at the concentration of 2010 mg/kg bw. No mortality was observed at 2010 mg/kg bw. Therefore, LD50 was considered to be > 2010 mg/kg bw, when rabbits were treated with 2-ethylhexanoyl chloride (760-67-8) by dermal application.
The above study supported by U. S. Environmental Protection Agency (2012), for the structurally similar read across substanceBenzoyl chloride (98-88-4).The acute dermal toxicity was tested in Male and Female New Zealand White rabbits (2/sex) at the concentration of 2000 mg/kg bw to the unabraded or abraded skin under occluded conditions for 24 hours. The hair was clipped from the backs of 2 male and 2 female rabbits; the skin of 1 male and 1 female was abraded. The test compound was applied only once to the back of each animal at a dose of 2000 mg/kg. The area was wrapped with gauze and plastic wrap. 24 hours later, the bandages were removed and the backs washed with tepid water. No mortality was observed at 2000 mg/kg bw; whereas, all rabbits exhibited fissuring on the site of application with normal body weight gains observed in 3 out of 4 rabbits. Therefore, LD50 was considered to be > 2000 mg/kg bw, when Male and Female New Zealand White rabbits were treated with Benzoyl Chloride (CASRN 98-88-4) by dermal application to the abraded skin under occluded conditions for 24 hours.
Thus, based on the above studies on 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS no: 16883-16-2) and it’s read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 5-methyl-3-phenylisoxazole-4-carbonyl chloride can be classified as category V of acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies and prediction on 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS no: 16883-16-2) and it’s read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 5-methyl-3-phenylisoxazole-4-carbonyl chloride can be classified as category V for acute oral and dermal toxicity.
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