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EC number: 272-028-3 | CAS number: 68649-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from TSCATS
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral study in rats
- Author:
- Toxic Substances Control Act Test Submissions (TSCATS)
- Year:
- 2 006
- Bibliographic source:
- United States Environmental Protection Agency (EPA),2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts (89-92 %) in male rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- EC Number:
- 272-028-3
- EC Name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- Cas Number:
- 68649-42-3
- Molecular formula:
- C28H60O4P2S4Zn
- IUPAC Name:
- Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Test animals
- Species:
- rat
- Strain:
- other: Charles River
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 1350, 2025, 3038, 4556, 5000 and 6834 mg/kg bw
- No. of animals per sex per dose:
- Total: 35
1350 mg/kg: 5 male
2025 mg/kg: 5 male
3038 mg/kg: 5 male
4556 mg/kg: 5 male
5000 mg/kg: 10 male
6834 mg/kg: 5 male - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on day fist and on 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology were examined. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 195 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival, body weight, gross pathology
- Mortality:
- When treated with 6834 mg/kg bw, all animals died within 6-22 hours.
When treated with 5000 mg/kg bw, 7 animals died within 3-4 days.
When treated with 4556 mg/kg bw, 4 animals died within 2-3 days.
When treated with 3038 mg/kg bw, 2 animals died in 3 days.
When treated with 2025 mg/kg bw, 1 animals died in 3 days.
When treated with 1350 mg/kg bw, no mortality were observed in treated rats. - Clinical signs:
- other: Hypoactivity, ptosis, ruffed fur, muscular weakness and Diarrhea were observed in treated rats.
- Gross pathology:
- Slightly reddened lungs were observed in dead animals and no gross pathological changes were observed in terminally sacrificed rats.
- Other findings:
- not specified
Any other information on results incl. tables
1. Mortality and Body Weight Data:
Dose Level (mg/kg) |
Animal number |
Individual Body Weight (grams) |
Number Dead/Number Tested |
Percent Dead |
|
Test day number: |
|||||
0 |
14 |
||||
1350 |
1 2 3 4 5 |
196 214 22 204 216 |
306 342 364 320 346 |
0/5 |
0 |
2025 |
6 7 8 9 10 |
260 298 254 274 312 |
358 (3 days) 340 390 420 |
1/5 |
20 |
3038 |
11 12 13 14 15 |
320 288 246 354 260 |
396 366 308 (3 days) (3 days) |
2/5 |
40 |
4556 |
16 17 18 19 20 |
246 246 288 256 320 |
368 (6-22 hours) (3 days) (2 days) (3 days) |
4/5 |
80 |
5000 |
21 22 23 24 25 26 27 28 29 30 |
180 188 190 200 184 164 184 178 186 192 |
(3 days) 266 (3 days) 308 (4 days) (4 days) (3 days) (4 days) 290 (4 days) |
7/10 |
70 |
6834 |
31 32 33 34 35 |
318 302 244 300 264 |
(6-22 hours) (6-22 hours) (6-22 hours) (2 days) (6-22 hours) |
5/5 |
100 |
Note: Figures in parentheses indicate time of death
2. Reactions and Pathology
The pharmacotoxic symptoms exhibited by the rats post-oral administration of MRD-ECH-75-19 are presented below:
Reaction |
Dose Levels (mg/kg) |
|||||||||||
1350 |
2025 |
3038 |
4556 |
5000 |
6834 |
|||||||
O |
R |
O |
R |
O |
R |
O |
R |
O |
R |
O |
R |
|
HYPOACTIVITY |
- |
- |
4 H |
2 D |
4 H |
3 D |
4 H |
3 D |
4 H |
4 D |
2 H |
N |
PTOSIS |
- |
- |
- |
- |
4 H |
3 D |
4 H |
3 D |
4 H |
4 D |
2 H |
N |
RUFFED FUR |
- |
- |
6-22 H |
2 D |
4 H |
3 D |
4 H |
3 D |
4 H |
4 D |
2 H |
N |
MUSCULAR WEAKNESS |
- |
- |
6-22 H |
2 D |
4 H |
3 D |
4 H |
3 D |
4 H |
4 D |
2 H |
N |
DIARRHEA |
- |
- |
6-22 H |
2 D |
1 H |
2 D |
1 H |
2 D |
1 H |
4 D |
1 H |
N |
O = Onset H = Hours M =Minutes
R = Recovery D = Days N =No recovery - = No reaction
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3195 mg/kg bw when CD male rats were treated with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts orally by gavage.
- Executive summary:
In a acute oral toxicity study,Charles River male rats were treated with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts in the concentration of1350, 2025, 3038, 4556, 5000 and 6834 mg/kg bw orally by gavage and observed for 14 days. All animals died within 6-22 hours at 6834 mg/kg bw, 7 animals died within 3-4 days at 5000 mg/kg bw, 4 animals died within 2-3 days at 4556 mg/kg bw, 2 animals died in 3 days at 3038 mg/kg bw, 1 animals died in 3 days at 2025 mg/kg bw and no mortality were observed in treated rats at 1350 mg/kg bw. Hypoactivity, ptosis, ruffed fur, muscular weakness and Diarrhea were observed in treated rats. Slightly reddened lungs were observed in dead animals and no gross pathological changes were observed in terminally sacrificed rats. Therefore,LD50 was considered to be3195 mg/kg bw when CD male rats were treated with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts orally by gavage.
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