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EC number: 700-890-7 | CAS number: 503614-91-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 15 February and 03 March 2012.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- Principles of method if other than guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- GLP compliance:
- yes
- Type of method:
- sieving
- Type of distribution:
- other: Sieving Screening Test, Cascade Impactor
- Remarks on result:
- not determinable because of methodological limitations
- Percentile:
- D50
- Remarks on result:
- not determinable
- No.:
- #1
- Size:
- < 100 other: µm
- Distribution:
- 13.8 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- <= 5.58 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- <= 0.83 %
- Conclusions:
- Conclusion
Particle size data acquired for the test item is shown in the following table:
Table 3.22
Measurement Method Result
Proportion of test item having an Sieve 13.8 %
inhalable particle size <100 µm
Proportion of test item having a Cascade Impactor ≤5.58 %
thoracic particle size <10.0 µm
Proportion of test item having a Cascade Impactor ≤0.830 %
respirable particle size <5.5 µm - Executive summary:
Performance of the Test
Sieving Screening Test
The proportion of test item passing through a 100 µm sieve was determined using an Inclyno sieve shaker. A known mass (15.18 g) of test item was added to a 100 µm sieve fitted above a receiver pan of known mass. A lid was then secured onto the sieve and the assembled apparatus placed on the sieve shaker for a period of approximately 30 minutes. Following the shaking period, the mass of the receiver pan and collected test item was recorded and the percentage test item with a particle size <100 µm calculated as detailed in the data handling section.
Cascade Impactor
Test item (approximately 3 g) was passed into the artificial throat of a Marple Miller Cascade Impactor (MSP Corporation, Minneapolis, Minnesota, USA – Figure 3.4 - Attachment 1). During cascade impactor analysis, air was pulled through the impactor, by a vacuum pump, at a flow rate of approximately 60 L/min. The flow enters the impactor through a throat and inlet tube and accelerates through the stages. At each stage one or more nozzles direct the particle-laden airstream into a collection cup.
Particles larger than the cut size of that stage, impact onto the collection plate and stay in the collection cup. Smaller particles follow the airstream and are carried to the next stage. In succeeding stages the nozzles are smaller, the air velocity is higher and finer particles are collected. In the final stage the smallest particles are collected on a glass fibre filter. The mass of the collection cups and filter were recorded before and after each determination.
Conclusion
Particle size data acquired for the test item is shown in the following table:
Table 3.22
Measurement
Method
Result
Proportion of test item having an inhalable particle size <100 µm
Sieve
13.8 %
Proportion of test item having a thoracic particle size <10.0 µm
Cascade Impactor
≤5.58 %
Proportion of test item having a respirable particle size <5.5 µm
Cascade Impactor
≤0.830 %
Reference
Results
Screening test (sieve method)
The results of the sieving procedure are shown in the following table:
Table 3.16
Measurement |
Result |
Mass of test item transferred to sieve |
15.18 g |
Mass of test item passed through sieve |
2.10 g |
Proportion of test item <100 µm |
13.8 % |
Definitive test
The results of the cascade impactor method determinations are shown as follows:
Determination 1
Table 3.17
Collection Stage |
Particle Size Range Collected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.1543 |
88.7816 |
2.6273 |
Cup 2 |
5.5 to 10.0 |
85.6025 |
85.6433 |
0.0408 |
Cup 3 |
2.4 to 5.5 |
85.9395 |
85.9548 |
0.0153 |
Cup 4 |
1.61 to 2.4 |
85.7216 |
85.7288 |
0.0072 |
Cup 5 |
0.307 to 1.61 |
85.8571 |
85.8573 |
0.0002 |
Filter |
<0.307 |
75.5386 |
75.5404 |
0.0018 |
Mass of test item found in artificial
throat: 0.26 g.
Total mass of test item recovered from artificial throat, sample cups
and filter: 2.95 g.
Determination 2
Table 3.18
Collection Stage |
Particle Size Range Collected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.1168 |
88.6874 |
2.5706 |
Cup 2 |
5.5 to 10.0 |
85.5581 |
85.6647 |
0.1066 |
Cup 3 |
2.4 to 5.5 |
85.9077 |
85.9158 |
0.0081 |
Cup 4 |
1.61 to 2.4 |
85.6864 |
85.6876 |
0.0012 |
Cup 5 |
0.307 to 1.61 |
85.8565 |
85.8578 |
0.0013 |
Filter |
<0.307 |
75.5343 |
75.5369 |
0.0026 |
Mass of test item found in artificial
throat: 0.28 g.
Total mass of test item recovered from artificial throat, sample cups
and filter: 2.97 g.
Determination 3
Table 3.19
Collection Stage |
Particle Size Range Collected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.1163 |
88.8757 |
2.7594 |
Cup 2 |
5.5 to 10.0 |
85.5566 |
85.7113 |
0.1547 |
Cup 3 |
2.4 to 5.5 |
85.9078 |
85.9201 |
0.0123 |
Cup 4 |
1.61 to 2.4 |
85.6859 |
85.6877 |
0.0018 |
Cup 5 |
0.307 to 1.61 |
85.8575 |
85.8579 |
0.0004 |
Filter |
<0.307 |
75.5385 |
75.5419 |
0.0034 |
Mass of test item found in artificial
throat: 0.16 g.
Total mass of test item recovered from artificial throat, sample cups
and filter: 3.09 g.
Cumulative amounts
The cumulative amounts of test item found in the three determinations for the individual particle size cut-points are shown in the following table:
Table 3.20
Particle Size Cut-point (µm) |
Cumulative Mass (g) |
Cumulative Percentage (%) |
||||
Determination 1 |
Determination 2 |
Determination 3 |
Determination 1 |
Determination 2 |
Determination 3 |
|
10.0 |
0.0653 |
0.1198 |
0.1726 |
2.21 |
4.03 |
5.58 |
5.5 |
0.0245 |
0.0132 |
0.0179 |
0.830 |
0.444 |
0.579 |
2.4 |
0.0092 |
0.0051 |
0.0056 |
0.312 |
0.172 |
0.181 |
1.61 |
0.0020 |
0.0039 |
0.0038 |
6.8 x 10-2 |
0.131 |
0.123 |
0.307 |
0.0018 |
0.0026 |
0.0034 |
6.1 x 10-2 |
8.8 x 10-2 |
0.110 |
The overall cumulative percentage (%) of test item with a particle size less than 10.0 µm and 5.5 µm are shown in the following table:
Table 3.21
Particle size |
Cumulative Percentage (%) |
|||
Determination 1 |
Determination 2 |
Determination 3 |
Overall |
|
<10.0 µm |
2.21 |
4.03 |
5.58 |
≤5.58 |
<5.5 µm |
0.830 |
0.444 |
0.579 |
≤0.830 |
Particle size data acquired for the test item is shown in the following table:
Table 3.22
Measurement |
Method |
Result |
|||
Proportion of test item having an inhalable particle size <100 µm |
Sieve |
13.8 % |
|||
Proportion of test item having a thoracic particle size <10.0 µm |
Cascade Impactor |
≤5.58 % |
|||
Proportion of test item having a respirable particle size <5.5 µm |
Cascade Impactor |
≤0.830 % |
Description of key information
Following measurement of particle size according to OECD Guideline 110, the following fractions were determined:
Proportion of test item having an inhalable particle size <100 µm: 13.8 %; proportion of test item having a thoracic particle size <10.0 µm: ≤5.58 %;
proportion of test item having a respirable particle size <5.5 µm: ≤0.830 %.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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