Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-752-3 | CAS number: 13474-25-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-1-vinyl-1H-imidazolium chloride
- EC Number:
- 236-752-3
- EC Name:
- 3-methyl-1-vinyl-1H-imidazolium chloride
- Cas Number:
- 13474-25-4
- Molecular formula:
- C6H9N2.Cl
- IUPAC Name:
- 1-ethenyl-3-methyl-2,3-dihydro-1H-imidazol-1-ium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. k. Thomae GmbH, Biberach, Germany
- Weight at study initiation: animals of comparable weight (+/- 20 % of mean weight)
- Fasting period before study: 16 hours
- Housing: in groups of 5 separated by sex
- Diet: Kliba Labordiaet, Klingenthalermuele, Kaiseraugst, Switzerland, ad libitum
- Water:Tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50, 38.3, 26.1 % (w/v)
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 2610, 3830, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: twice daily on working days, at least once on weekends and public holidays
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 values were determined by probit analysis according to Finney et al. (1971)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 660 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 780 mg/kg bw
- 95% CL:
- 4 220 - 6 830
- Mortality:
- 5000 mg/kg dose level: 4/5 males, 2/5 females
3830 mg/kg dose level: 0/5 males, 1/5 females
2610 mg/kg dose level: 0/5 males, 0/5 females - Clinical signs:
- nothing abormal reported
- Body weight:
- nothing abnormal reported; all animals showed slight to normal body weight gain during the observation period
- Gross pathology:
- Deceased animals: general congestive hyperemia
Sacrificed animal: nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
