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EC number: 600-337-9 | CAS number: 102691-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 13th 2018 to December 20th 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- 2015
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
- EC Number:
- 600-337-9
- Cas Number:
- 102691-36-1
- Molecular formula:
- C15H32N3OP
- IUPAC Name:
- 3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
- Test material form:
- liquid
- Details on test material:
- clear, colourless liquid
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- The test was performed on a total of 4 membrane discs with bio-barrier matrix together with a negative and positive control. A disc was placed on a vial with CDS fluid. The test item (500 μL) was applied on top of the matrix within two minutes after the disc was placed on the CDS fluid. One disc was exposed to 500 μL citric acid (10%, negative control) and one disc was exposed to 500 mg of the positive control sodium hydroxide. The test item and controls
were evenly distributed. - Duration of treatment / exposure:
- The test item was classified into one of the two timescale categories.
The timescale category test showed that the test item is a timescale 2 item. No color change was observed in tube A and B, therefore the addition of the confirm reagent to tube B was performed. The addition of confirm reagent led to a color change of tube B into grey/purple indicating that the test item is a timescale 2 item.
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Value:
- > 60
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, the substance is classified as non-corrosive in the Corrositex® assay under the experimental conditions described in this report.
- Executive summary:
The objective of this study was to evaluate the substance in the in vitro membrane barrier test for skin corrosion using Corrositex®.
For this purpose the test item was topically applied on top of a bio-barrier and the ability of the test item to pass through a bio-barrier and to elicit a color change in the underlying liquid
chemical detection system was evaluated.
The test item compatibility test showed that the test item was compatible with the chemical detection system. Based on the acid or alkali reserve of the chemical the test item was classified as a
timescale 2 compound. The test item was applied undiluted (500 μL) on top of the bio-barrier matrix. The elapsed time between application and penetration was determined by monitoring changes in the
chemical detection system. The test item did not penetrate through the membrane (mean penetration time >60 minutes).
The test passed all acceptance criteria:
a) The negative control citric acid (10%) showed a mean penetration time of >60 minutes and was therefore non-corrosive.
b) The positive control sodium hydroxide (as it is) breakthrough time (15 minutes) falls within within ± two standard deviations of the positive control historical mean breakthrough time.
c) The positive control sodium hydroxide (as it is) showed a mean penetration time of 15 minutes and was therefore classified as UN packing group II (=GSH 1B).
Overall it was concluded that the test system functioned properly. Since the test item was a timescale 2 test item and showed a mean penetration time of >60 minutes, the test item is
classified as non-corrosive.
In conclusion, The substance is classified as non-corrosive in the Corrositex® assay under the tested experimental conditions.
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