3,7-dimethylocta-1,3,6-triene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

1

Reference substance name:

3,7-dimethylocta-1,3,6-triene

EC Number:

237-641-2

EC Name:

3,7-dimethylocta-1,3,6-triene

Cas Number:

13877-91-3

Molecular formula:

C10H16

IUPAC Name:

3,7-dimethylocta-1,3,6-triene

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

not specified

Doses:

5.0 g/kg bw

No. of animals per sex per dose:

7 animals (sex unspecified)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

1/7 animal died on day 7 of the observation period

Clinical signs:

- Anorexia in the animal which died
- Moderate redness and moderate edema was seen in all 7 animals.

Applicant's summary and conclusion

Interpretation of results:

other: Not acutely harmful

Remarks:

in accordance with CLP (1272/2008 and its updates)

Conclusions:

The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw.

Executive summary:

A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance.In this study 7 rabbits (sex unspecified) were administered with 5000 mg/kg test substance on the skin. 1/7 animals died on day 7 of the 14 day observation period after exposure to the test substance. Anorexia was observed in this animal and moderate redness and moderate edema was seen in all 7 animals. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/ kg bw. Based on these results, the test substance is not considered to be acutely harmful.