Registration Dossier
Registration Dossier
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EC number: 700-845-1 | CAS number: 133978-15-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No experimental studies on mutagenicity of 1-methylheptyl 2-cyanoacrylate in Salmonella typhimurium are available.
In general, 2-cyanoacrylates are a family of fast-reacting adhesives. The cyanoacrylate monomers rapidly polymerize in the presence of water to form long, strong chains. The reaction is faster for small chain cyanoacrylates compared to the longer chain homologes.
As can be seen from the weight-of-evidence from studies on mutagenicity (namely the Salmonella typhimurium mutagenicity assay - Ames test), ethyl, allyl, butyl, and iso-butyl 2-cyanoacrylates did not show any mutagenicity under the tests conditions described. Only for methyl 2-cyanoacrylate there was an indication of a mutagenic potential in one strain (TA 100). The other strains did not indicate mutagenicity, so the result of the various Ames tests can be considered as ambiguous for methyl 2 -cyanoacrylate.
As no mutagenicity was observed in the Ames tests for the series of longer-chained 2 -cyanoacrylates, it can be concluded in an expert judgement based on analogy considerations that also 1-methylheptyl 2-cyanoacrylate will not be mutagenic in the Salmonella typhimurium mutagenicity assay (Ames test). The analogy is justified by structural similarity and the same reaction mechanism.
Short description of key information:
- REACH_negative | Salmonella typhimurium TA 1535, TA 1537, TA 98, TA 100 | OECD 471 (Ames test) | with and without | [TN]1-butyl cyanoacrylate [/TN][SPEC][/SPEC][AM]97%[/AM]#Analogy#
- REACH_negative/ambigous | Salmonella typhimurium TA 1535, TA 1537, TA 98, TA 100 | OECD 471 (Ames test) | with and without | [TN]2-cyanoacrylates[/TN][SPEC][/SPEC][AM][/AM]#Analogy'
- REACH_negative/ambigous | Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 |OECD 471 (Ames test) | with and without | [TN]2-cyanoacrylates[/TN][SPEC][/SPEC][AM]>98%[/AM]#Analogy#
- REACH_negative | Salmonella typhimurium TA 1535, TA 100 | Plate incorporation test and volatile spot test | without | [TN]2-cyanoacrylates[/TN][SPEC][/SPEC][AM][/AM]#Analogy#
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The overall weight-of-evidence regarding the behaviour of structurally well comparable 2 -cyanoarylates (ethyl, allyl, butyl, iso-butyl-) gives no indication to assume a mutagenic activity of those substances in the bacterial mutagenicity assay with Salmonella typhimurium (Ames test). Based on a good similarity regarding the structure of 1-methylheptyl 2-cyanoarylate (longer chain length) and a comparable reaction mechanism it is concluded in an expert judgement that 1 -methylheptyl 2 -cyanoacrylate is also considered non-mutagenic in the Ames test resulting in no classification.
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