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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
concentration x time method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Violanthrene-5,10-dione
EC Number:
204-152-0
EC Name:
Violanthrene-5,10-dione
Cas Number:
116-71-2
Molecular formula:
C34H16O2
IUPAC Name:
violanthrene-5,10-dione
Test material form:
solid: particulate/powder
Details on test material:
Vat Blue 20

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks:
saturated with test item at 20°C
Details on inhalation exposure:
Inhalation by means of vapour saturated at 20°C for 8 hours. To achieve saturation, air was fed through an approx. 5 cm deep layer of the product.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
saturation concentration
No. of animals per sex per dose:
12 rats
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily observation
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, necropsy
Statistics:
NA

Results and discussion

Preliminary study:
NA
Effect levels
Sex:
not specified
Dose descriptor:
LC0
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: no effect at saturation concentration
Mortality:
no deaths
Clinical signs:
other: no effects
Body weight:
no data
Gross pathology:
no effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
8 hours inhalation of a saturated athmosphere did not lead to any deaths in rats (0/12)