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EC number: 201-989-3 | CAS number: 90-40-4
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is predicted using OECD QSAR tool box v.3.4 using log kow as primary descriptor. The test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid showed 0.366 % biodegradation by considering BOD as parameter and microorganisms as inoculums in 28 days. By this value of percent biodegradation the test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is considered to be not readily biodegradable.
Biodegradation in water and Sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No: 90-40-4) .If released in to the environment, 11.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 3-amino-5-hydroxynaphthalene-2, 7-disulfonic acid in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.01%), indicates that test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is not persistent in sediment.
Biodegradation in Soil:
The half-life period of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No: 90-40-4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 87.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
Predicted data for the target compound 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No.90-40-4) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Biodegradability of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is predicted using OECD QSAR tool box v.3.4 using log kow as primary descriptor. The test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid showed 0.366 % biodegradation by considering BOD as parameter and microorganisms as inoculums in 28 days. By this value of percent biodegradation the test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is considered to be not readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to predict the biodegradation potential of the test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid(CAS No: 90-40-4) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acidis not readily biodegradable.
In the supporting weight of evidence study from authoritative database (J check, 2017) of read across chemical dipotassium7-hydroxynaphthalene-1, 3-disulfonate (CAS no. 842-18-2) was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD parameter. The initial concentration of read across chemical was 100 mg/L and study design is of standard type. After 4 weeks read cross chemical showed 0% biodegradation by BOD parameter so it is concluded that it is not readily biodegradable.
In another supporting weight of evidence study from authoritative database (J check, 2017) the read across chemical Sodium 5-amino-4-hydroxy-7-sulfonaphthalene-2-sulfonate (CAS no. 5460-09-3) was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using O2 consumption (BOD), TOC removal and test material analysis by UV vis parameter. The initial concentration of read across chemical was 100 mg/L and study design is of standard type. After 2 weeks (14 days) read across chemical Sodium 5-amino-4-hydroxy-7-sulfonaphthalene-2-sulfonate showed 0% biodegradation by O2 consumption (BOD) parameter, 5 % biodegradation by TOC removal parameter and less than 0 % biodegradation by test material analysis by UV Vis parameter in 14 days. So it is concluded that this read across chemical is not readily biodegradable.
On the basis of above results for target chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No: 90-40-4) from ( EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances ( from authoritative database) the target chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid can be expected to be not readily biodegradable.
Biodegradation in water and Sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No: 90-40-4) .If released in to the environment, 11.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 3-amino-5-hydroxynaphthalene-2, 7-disulfonic acid in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 2% (i.e, reported as 1.01%), indicates that test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid is not persistent in sediment.
Biodegradation in Soil:
The half-life period of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS No: 90-40-4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 87.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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