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Diss Factsheets
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EC number: 701-138-0 | CAS number: 242482-67-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data on toxicokinetics, metabolism and distribution of the submission substance are available. Based on the physicochemical properties of the submission substance it is anticipated that the substance is bioavailable via the oral, dermal or inhalation route. Beta oxidation or direct hydrolysis are thought to be reasonable metabolism pathways leading to systemic exposure to 3,5,5-trimethylhexanoic acid. Given the results from repeated dose experiments no concern for bioaccumulation is raised.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The submission substance is a 2,2',2''-nitrilotriethanol (TEA) salt of 6 -(isononanoylamino)hexanoic acid. A spontaneous conversion to acid is expected in aqueous system or in biological fluid. The relevant chemical species for uptake and systemic exposure is the acid. Thus the kinetic profile will be derived for 6 -(isononanoylamino)hexanoic acid.
6 -(Isononanolyamino)hexanoic acid is pected to be bioavailable for oral/dermal/inhalation routes based on the given molecular size (MW of 422.6; MW of the corresponding acid 271.4 g/mol) and the octanol water partition coefficient (LogPow of -0.6; LogPow of the corresponding acid 2.47). No metabolism or kinetic study is available on the submission substance or its corresponding acid. Based on the structural analysis and the indication obtained in the microbial degradation study (metabolite identification in samples of Zahn-Wellens Test), two degradation pathways can be reasonably derived:
- Beta oxidation at the terminal carboxylic acid moiety in combination with hydrolysis at amide bond
- Direct hydrolysis at the amide moiety
Both pathways are leading to systemic exposure to 3,5,5-trimethylhexanoic acid, which serves as surrogates of the proposed read-across approach.
The submission substance as well as the presumed metabolite 3,5,5-trimethylhexanoic acid caused effects on liver and kidney upon 28-day oral treatment in rats and these effects were fully reversible within recovery period of 14 days. No concern with respect to the bioaccumulation can be derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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