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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
Isobutyl 2-naphthyl ether
EC Number:
218-529-2
EC Name:
Isobutyl 2-naphthyl ether
Cas Number:
2173-57-1
Molecular formula:
C14H16O
IUPAC Name:
isobutyl 2-naphthyl ether
Test material form:
other: solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Observations: mortality, clinical signs
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
3 out of 10 animals died. One animal on day 1 and two on day 2.
Clinical signs:
Clinical signs observed included diarrhea, lethargy, ptosis and piloerection.
Gross pathology:
Upon necrosy the following results were revealed: 5/10 animals were normal; 1/10 animals were cannibalized; red exudate in the nose/mouth in 1/10 animals; yellow exudate in the nose/mouth in 1/10 animals; yellow anogenital exudate in 2/10 animals; red areas in the intestines in 2/10 animals; bloated intestines in 1/10 animals; red areas in the stomach in 1/10 animals; dark liver in 3/10 animals; mottled liver in 1/10 animals; dark lungs in 2/10 animals; dark kidney in 3/10 animals.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Remarks:
According to Regulation (EC) No. 1272/2008 and its updates
Conclusions:
The acute oral toxicity test showed an LD50 > 5000 mg/kg bw
Executive summary:

In a pre-GLP acute toxicity study similar to OECD 401, 10 rats were orally exposed to 5000 mg/kg bw test substance. 3 out of 10 animals died. Clinical signs observed included diarrhea, lethargy, ptosis and piloerection. Upon necropsy the following results were revealed: 5/10 animals were normal; 1/10 animals were cannibalized; red exudate in the nose/mouth in 1/10 animals; yellow exudate in the nose/mouth in 1/10 animals; yellow anogenital exudate in 2/10 animals; red areas in the intestines in 2/10 animals; bloated intestines in 1/10 animals; red areas in the stomach in 1/10 animals; dark liver in 3/10 animals; mottled liver in 1/10 animals; dark lungs in 2/10 animals; dark kidney in 3/10 animals. Under the conditions of the test the acute oral LD50 was determined to be >5000 mg/kg bw in rats.