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EC number: 268-159-0 | CAS number: 68015-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 September 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- Limited scopes for methodological differences with an acute dermal toxicitystudy, therefore should be suitable to be used. As the study has been conducted on the susbtance and the toxicity profile is consistent, to prevent use of unnecessary animal testing this data should be considered and used.
Data source
Reference
- Reference Type:
- other: Study abstract
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Octadec-2-enylsuccinic acid
- EC Number:
- 268-159-0
- EC Name:
- Octadec-2-enylsuccinic acid
- Cas Number:
- 68015-93-0
- Molecular formula:
- C22H40O4
- IUPAC Name:
- 2-octadec-2-en-1-ylsuccinic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Physical Description Brown Solid
Test material was grounded and applied as an aqeous slurry
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No Data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The test skin of all animals were abraded
- Doses:
- 200, 794, 3160 mg/kg
- No. of animals per sex per dose:
- 2 males and 2 females per dose
- Control animals:
- no
- Details on study design:
- Animals were treated dermally as an aqeous paste made from grounded test substance. Animals were observed for 14 Days for signs of mortality and clinical signs. Macrospic evaluation was performed at the end of the study.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Motality was observed in 1/4 animals at 794 and at 3160 mg/kg
- Clinical signs:
- other: The material was severely irritating to the skin was observed through the observation period. Pale red to red, well-defined erythema, moderate edema and second degree burns at 200 mg/kg were observed. Pale red to red, well-defined erythema, severe edema a
- Gross pathology:
- No test related findings.
Any other information on results incl. tables
Dose Level (mg/kg) |
Animal Number and Sex |
Mortality |
200 |
1-M |
0/4 |
2-M |
||
3-F |
||
4-F |
||
794 |
5-M |
1/4 |
6-M |
||
7-F |
||
8-F |
||
3160 |
9-M |
1/4 |
10-M |
||
11-F |
||
12-F |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- LD50 = 3160 mg/kg
- Executive summary:
The objective of this study was to assess the adverse effects which can follow within a short period of time after a single dermal application of the Substanc.
The Substance was administered to 3 groups of male and female, albino rabbits. The study design was as follows:
Table1
Experimental DesignGroup
NumbersNumber of Animals
Dose Level
(mg/kg)1
2 Males & 2 Females
200
2
2 Males & 2 Females
794
3
2 Males & 2 Females
3160
The following parameters and end points were evaluated in this study: clinical signs, body weights, body weight changes, and on Day 14, gross necropsy findings.
Mortality was observed in 1 animal treated at 3160 mg/kg bw day and 1 animal treated at 794 mg/kg bw day. Decreases in Bodyweight effects were noted in surviving 3 animals treated at 3160 mg/kg at observation Day 7. By day 14, animal bodyweights had partially recovered back to starting weights in 2 animals. One animal's bodyweight remained similar to Day 7.
The material was severely irritating to the skin was observed through the observation period. Pale red to red, well-defined erythema, moderate oedema and second degree burns at 200 mg/kg were observed. Pale red to red, well-defined erythema, severe oedema and second degree burns at 794 and 3160 mg/kg were observed. Escharosis and fissuring were noted at all test sites of all survivors at 7 and 14 days. No macroscopic findings were considered to be test related findings.
Under the conditions of the study the median lethal dose level (LD50) of the Substance in albino rabbits were considered to be 3160 mg/kg.
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